reproductive medicine

不明原因不孕中 IVF 与 IUI 的比较：多中心随机对照试验中的疗效与安全性评估

Clinical Updates OB/GYN & Women's Health

IVF versus IUI in Unexplained Infertility: Evaluating Efficacy and Safety in a Multicenter RCT

By MedXY 11/07/2026

A landmark multicenter randomized trial reveals that first-line IVF yields higher live-birth rates than IUI with ovarian stimulation in unexplained infertility, with cumulative outcomes equalized after subsequent cycles.

news

Vitamin D Supplementation Fails to Boost IVF Success in Women with PCOS: Results from the VitD-PCOS Trial

By MedXY 02/23/2026

A large-scale multicenter RCT reveals that while 4000 IU/day of Vitamin D significantly raises serum 25-OHD levels in women with PCOS, it does not improve live birth rates following the first embryo transfer in IVF cycles.

Internal Medicine news

Antifibrotic Repurposing: How Finerenone Could Rejuvenate the Ovarian Niche and Restore Fertility in POI

By MedXY 02/07/2026

A breakthrough study in Science reveals that the antifibrotic drug finerenone restores fertility in premature ovarian insufficiency (POI) by reducing ovarian stromal fibrosis, enabling follicle development where hormone therapy previously failed.

news OB/GYN & Women's Health

Does Size Matter? Re-evaluating Endometrial Thickness Thresholds in 30,000 Euploid Embryo Transfers

By MedXY 12/26/2025

An international multicenter study confirms that endometrial thickness below 7 mm reduces live birth rates in most frozen embryo transfer protocols, though the impact is notably absent in natural cycles and overall predictive power remains modest.

news OB/GYN & Women's Health

Challenging the Compaction Paradigm: Why Endometrial Thinning May Not Predict Pregnancy Success in HRT-FET

By MedXY 12/26/2025

A large-scale analysis of over 16,000 cases reveals that endometrial compaction following progesterone administration does not improve pregnancy outcomes in HRT-FET, and may even be associated with lower success rates in blastocyst transfers.

news OB/GYN & Women's Health

Rethinking Mosaicism: Why Reporting Putative Mosaic Embryos Fails to Improve IVF Outcomes

By MedXY 12/24/2025

A large, double-blinded study reveals that reporting embryo mosaicism (ICN) during PGT-A provides no meaningful clinical predictive value for live birth rates, suggesting that current classification systems may unnecessarily limit embryo selection without improving overall success in routine IVF practice.

news

Optimising Ovulation Timing in Intrauterine Insemination: Evidence Still Unclear

By MedXY 12/18/2025

A Cochrane review finds no definitive evidence on the best method to synchronise insemination with ovulation in subfertile couples undergoing IUI.