Highlight
– ENTF brain stimulation therapy applied in the subacute phase post-ischemic stroke significantly increases the rate of patients achieving freedom-from-disability (mRS 0-1) at 8 to 12 weeks.
– Pooled analysis of two randomized, double-blind, sham-controlled trials (BQ3 and EMAGINE 1) including 124 patients confirmed improved disability outcomes and a favorable safety profile.
– The therapy led to a significant ordinal shift in disability levels and showed promising but non-significant benefits on upper extremity motor function.
– ENTF neuromodulation presents a promising non-invasive neurorehabilitation approach for moderate to severe post-stroke disability, warranting further large-scale investigations.
