The ARTEMIS trial demonstrated that a multimedia antistigma campaign effectively improves mental health-related knowledge, attitudes, and anticipated behavior among adolescents in Indian urban slums.
Primary care health worker-led digital interventions showed promising impact on depressive symptom reduction though remission differences did not reach statistical significance.
Cluster randomized controlled designs with high implementation fidelity are feasible in resource-limited, community-based adolescent populations.
Integrated strategies combining stigma reduction and digital mental health care can be a scalable model for adolescent mental health management in low- and middle-income countries (LMICs).
