insulin resistance

Oral Glucose Absorption Enhanced in Early Metabolic Dysfunction-Associated Steatotic Liver Disease

By MedXY 04/30/2026

New research reveals accelerated glucose absorption in early MASLD patients, independent of gastric emptying. This metabolic alteration may drive liver disease progression before hepatic insulin resistance develops.

Diabetes & Endocrinology Gastroenterology news

Early MASLD Is Associated With Enhanced Oral Glucose Absorption Independent of Gastric Emptying

By MedXY 04/30/2026

Stable-isotope OGTT data suggest that early MASLD is linked to higher oral glucose absorption, independent of gastric emptying, with preserved hepatic insulin suppression but impaired peripheral glucose clearance.

Diabetes & Endocrinology General Surgery news

Surgical Metabolic Intervention: Bariatric Surgery Transforms Outcomes in Type 1 Diabetes With Obesity

By MedXY 04/13/2026

A multicenter retrospective cohort study reveals that metabolic bariatric surgery in 162 adults with type 1 diabetes and obesity achieved 29.7% weight loss at one year, reduced insulin requirements by 57%, and significantly improved glycemic and lipid profiles, suggesting MBS as a viable option for this high-risk population.

Diabetes & Endocrinology news Respiratory

Insulin Resistance and Hyperinsulinemia: The Hidden Drivers of Lung Function Decline in Diabetes

By MedXY 03/20/2026

A comprehensive study combining the German Diabetes Study data and Mendelian randomization establishes a causal link between insulin resistance and reduced lung function (FEV1 and FVC), positioning the lung as a critical target for metabolic management in diabetic patients.

Diabetes & Endocrinology Internal Medicine news

OGTT-Derived Surrogate Indexes Outperform Fasting Measures in Predicting Type 2 Diabetes Risk: A Longitudinal Analysis

By MedXY 03/10/2026

A longitudinal study of 2,260 participants confirms that oral glucose tolerance test (OGTT)-based surrogate indexes, particularly Gutt and Cederholm, are superior to fasting-only measures in predicting type 2 diabetes, providing high clinical utility for metabolic risk stratification.

Cardiology Diabetes & Endocrinology news

Insulin Resistance Blunts LVAD-Mediated Myocardial Recovery by Impairing the Pentose Phosphate Pathway

By MedXY 03/02/2026

Obesity-induced insulin resistance hinders heart failure recovery post-LVAD by disrupting the pentose phosphate pathway. A new study in Circulation suggests insulin sensitizers could restore cardiac repair mechanisms in obese patients.

Cardiology Diabetes & Endocrinology news

Beyond Blood Sugar: Why Insulin Resistance Drives Vagal Dysfunction in Heart Failure

By MedXY 02/04/2026

Evidence from the Myovasc study reveals that insulin resistance and C-peptide levels are independent predictors of impaired cardiac vagal activity in heart failure, suggesting that metabolic health directly influences autonomic regulation beyond simple glycemic control.

Cardiology Diabetes & Endocrinology news

Insulin Metabolism as a Primary Driver of Cardiac Autonomic Dysfunction in Heart Failure: Insights from the Myovasc Study

By MedXY 02/03/2026

The Myovasc study demonstrates that insulin resistance and secretion markers, rather than glucose levels alone, are independently associated with impaired cardiac vagal activity in heart failure patients, suggesting a metabolic-autonomic axis that requires targeted clinical attention.

Diabetes & Endocrinology Neurology news

High Insulin Resistance Blunts the Superiority of Ticagrelor Over Clopidogrel in Minor Stroke Patients with CYP2C19 Mutations

By MedXY 01/22/2026

A post hoc analysis of the CHANCE-2 trial suggests that the clinical benefit of ticagrelor over clopidogrel for secondary stroke prevention in CYP2C19 loss-of-function carriers is significantly attenuated in patients with high insulin resistance.

Diabetes & Endocrinology news

Liraglutide Plus Metformin in Overweight/Obese PCOS: Greater Metabolic and Hormonal Benefits Than Metformin Alone

By MedXY 11/17/2025

A 2025 meta-analysis of 19 RCTs (n=1657) found liraglutide combined with metformin improved glycaemia, insulin resistance, BMI, sex hormones and lipids versus metformin alone in overweight or obese women with PCOS; evidence certainty was low due to heterogeneity and risk of bias.

Diabetes & Endocrinology news

Liraglutide Plus Metformin in Overweight/Obese PCOS: Greater Metabolic and Hormonal Benefits Than Metformin Alone

By MedXY 11/17/2025

Cardiology Diabetes & Endocrinology Specialties

Triglyceride Glucose-Waist Height Ratio Index as a Predictor of Cardiometabolic Multimorbidity in Chinese Middle-Aged and Older Adults: Insights from a National Prospective Cohort Study

By MedXY 10/19/2025

This study demonstrates that the triglyceride glucose-waist height ratio (TyG-WHtR) index independently predicts cardiometabolic multimorbidity risk in Chinese adults aged ≥45, showing a linear dose-response relationship and improved predictive performance over traditional metrics.

Cardiology Diabetes & Endocrinology news

Joint Impact of TyG-Related Indices and eGDR on Cardiometabolic Multimorbidity Risk in Chinese Adults: Insights from a Nationwide Cohort

By MedXY 10/19/2025

This study elucidates that high triglyceride glucose (TyG) related indices combined with low estimated glucose disposal rate (eGDR) synergistically elevate cardiometabolic multimorbidity (CMM) risk in middle-aged and older Chinese adults, enhancing early risk stratification and prevention strategies.

Cardiology Diabetes & Endocrinology Nephrology news

Insulin Resistance Indices as Predictors of Cardio-Renal-Metabolic Multimorbidity: Insights from the UK Biobank

By MedXY 10/19/2025

This study demonstrates that insulin resistance indices, particularly TyG-WC, TyG-WHtR, and METS-IR, robustly predict the risk and progression of cardio-renal-metabolic multimorbidity, with inflammation and kidney function mediating these associations.

Gastroenterology Internal Medicine news

Unraveling the Impact of Vitamin D Supplementation on Chronic Liver Disease: Insights from a Comprehensive Meta-Analysis

By MedXY 10/12/2025

Vitamin D supplementation in chronic liver disease modestly improves liver enzymes and insulin resistance, but shows no survival benefit or effects on liver stiffness and fat accumulation. Further large trials are needed to clarify its clinical role.

Clinical Updates Gastroenterology Internal Medicine news Specialties

Pan-PPAR Agonist Lanifibranor: A Breakthrough in Improving Insulin Resistance and Hepatic Steatosis in T2D and MASLD Patients

By MedXY 09/20/2025

Lanifibranor, a pan-PPAR agonist, significantly reduces liver fat and improves insulin sensitivity at multiple tissue sites in type 2 diabetes patients with MASLD, offering a new therapeutic avenue to address underlying metabolic dysfunction.

Cardiology Diabetes & Endocrinology Specialties

Untangling Adiposity and Insulin Resistance in HFpEF: Clarifying Their Distinct Impact on Cardiac Function

By MedXY 08/22/2025

This study reveals that excess adiposity, rather than insulin resistance or diabetes, predominantly drives left heart abnormalities and elevated pulmonary pressures in HFpEF, highlighting the need for targeted cardiometabolic therapies beyond glucose control.

Cardiology Specialties

Dynamic Triglyceride-Glucose Index Trajectories as Predictors of Mortality in Critically Ill Patients with Atrial Fibrillation

By MedXY 08/21/2025

A retrospective study shows high and fluctuating triglyceride-glucose (TyG) index trajectories predict increased short- and long-term mortality in ICU patients with atrial fibrillation, highlighting TyG dynamics as a valuable prognostic biomarker.

Cardiology news Specialties

Dynamic Triglyceride-Glucose Index Trajectories Predict Mortality in Critically Ill Atrial Fibrillation Patients

By MedXY 08/21/2025

This study reveals that fluctuating high triglyceride-glucose (TyG) index trajectories in critically ill atrial fibrillation patients significantly predict increased all-cause mortality up to one year post-ICU admission, offering a novel prognostic tool for risk stratification.

Clinical Updates Diabetes & Endocrinology news OB/GYN & Women's Health Specialties

Revealing Metabolic Subtypes in Gestational Diabetes Using Dynamic OGTT-Derived C-Peptide Trajectories: Implications for Personalized Risk and Management

By MedXY 08/21/2025

Dynamic C-peptide patterns during OGTT uncover metabolic heterogeneity in GDM, identifying insulin-resistant women at risk for fetal overgrowth and normoglycemic women at risk for preeclampsia, suggesting improved stratified treatment beyond glucose-based diagnosis.