DNAメチル化シグネチャーが痛風を無症候性高尿酸血症から見分ける――免疫・代謝関連遺伝子座との整合も確認
Posted inInternal Medicine news Rheumatology

DNA Methylation Signatures Distinguish Gout from Asymptomatic Hyperuricaemia and Align with Genetic Risk at Immune-Metabolic Loci

This study identifies specific DNA methylation patterns in blood that differentiate gout patients from those with asymptomatic hyperuricaemia and normouricaemic controls, linking epigenetic changes to immune-metabolic genetic risk factors and offering potential for molecular disease stratification.
Peripheral blood DNA methylation signatures show promise for predicting response to vedolizumab and ustekinumab in Crohn’s disease — EPIC‑CD findings
Posted inGastroenterology news Pathology & Lab Medicine

Peripheral blood DNA methylation signatures show promise for predicting response to vedolizumab and ustekinumab in Crohn’s disease — EPIC‑CD findings

An epigenome-wide study (EPIC‑CD) identified peripheral blood DNA methylation panels that predicted response to vedolizumab and ustekinumab (validated AUC 0.75 each) but failed to predict adalimumab response. Models worked best in biologic‑naïve patients and outperformed available clinical decision support tools.