Highlights
- Digital multimodal lifestyle intervention in multiple sclerosis (MS) demonstrated sustained improvements in physical and psychological functioning up to 24 months.
- Most significant behavioral changes and sustained benefits were observed in dietary adherence and body mass index, emphasizing the importance of nutrition.
- Physical activity adherence did not show significant improvement, highlighting challenges in sustaining exercise behaviors in MS populations.
- Findings underscore the complementary role of lifestyle strategies alongside disease-modifying therapies for long-term MS management.
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For clinical reference; use professional judgment.

