Regular colonoscopic surveillance (≤3-year interval) in Lynch syndrome (LS) patients correlates with reduced colorectal cancer (CRC) mortality and all-cause mortality.
No significant reduction in overall CRC incidence was observed with surveillance, suggesting complex detection dynamics.
Shorter surveillance intervals (≤2 years) were associated with increased detection of CRC, particularly early-stage, with no corresponding late-stage reduction, indicating possible overdiagnosis or lead-time bias.
Findings highlight potential selection biases inherent to a non-randomized observational design and emphasize the need for careful interpretation of surveillance benefits.
