Respiratory – Page 11

Twice-Yearly Depemokimab Maintained Asthma Control After Switching From Mepolizumab or Benralizumab, but Did Not Meet Formal Noninferiority for Exacerbations

By MedXY 05/29/2026

In the phase 3A NIMBLE trial, switching biologic-responsive severe asthma patients to twice-yearly depemokimab preserved overall control and showed comparable safety, but formal noninferiority versus continued mepolizumab or benralizumab for exacerbations was not achieved.

Critical Care news Respiratory

Prone Positioning for Severe Hypoxemia Rose Sharply During COVID-19 but Was Not Sustained Across North American ICUs

By MedXY 05/27/2026

In 37 North American hospitals, proning of eligible mechanically ventilated patients increased markedly during COVID-19, then fell post-pandemic, with substantial interhospital variation throughout.

news Public Health Respiratory

COPD Cuts Life Expectancy in a Severity-Dependent Manner, With Losses Comparable to or Greater Than Diabetes and Smoking

By MedXY 05/27/2026

A large pooled US cohort study found that COPD substantially reduces life expectancy, even among never-smokers, with years of life lost increasing progressively from GOLD stage 1 through stage 4.

news Public Health Respiratory Transplantation

Where a Lung Transplant Candidate Is Listed Still Shapes Access to Donor Lungs Under U.S. Continuous Distribution

By MedXY 05/27/2026

A national SRTR analysis shows that transplant center geography still strongly influences effective donor access after CAS implementation, and the 2026 proximity-weighted amendment is likely to widen disparities, especially for biologically harder-to-match candidates.

news Public Health Respiratory

Motivational Interviewing and Air Cleaners for Smokers with COPD (MOVE): A Randomized, Double-Blind, Placebo-Controlled Trial

By MedXY 05/27/2026

Portable HEPA air cleaners plus motivational interviewing improved symptoms and quality of life in smokers with COPD by reducing indoor particulate matter, though lung function and exacerbations did not significantly change.

Critical Care news Respiratory

Out-of-Bed Armchair Positioning Improves Oxygenation in Spontaneously Breathing ICU Patients

By MedXY 05/23/2026

A randomized ICU trial found that sitting spontaneously breathing patients in an armchair for 3 hours improved oxygenation more than staying semi-recumbent in bed, with no serious adverse events.

Internal Medicine news Respiratory

Effectiveness of Automatically-Adjusted vs Manually-Adjusted Noninvasive Ventilation in Obesity Hypoventilation Syndrome: A Randomized Clinical Trial

By MedXY 05/21/2026

In ambulatory patients with obesity hypoventilation syndrome, automatically-adjusted noninvasive ventilation was as effective as manually adjusted NIV over 12 months and more cost-effective, offering a simpler path to treatment.

Cardiology news Respiratory

Dual versus monotherapy pretreatment before balloon pulmonary angioplasty in CTEPH: effects on complications and outcomes

By MedXY 05/18/2026

In CTEPH patients undergoing balloon pulmonary angioplasty, dual pulmonary hypertension-targeted pretreatment was linked to fewer thoracic complications and better 6-month clinical improvement than monotherapy.

Infectious Diseases news Respiratory

Lower Airway Dysbiosis in NTM-Positive Bronchiectasis Is Linked to NET-Dominant Severe Phenotypes

By MedXY 05/18/2026

In NTM-positive bronchiectasis, lower airway dysbiosis involving Mycobacterium and oral bacteria is linked to higher NET levels and more severe disease phenotypes, suggesting that the broader airway microbiome may shape inflammation and outcomes.

Cardiology news Respiratory

Cardiovascular Benefit of CPAP May Be Greater in High-Risk Obstructive Sleep Apnoea

By MedXY 05/15/2026

This pooled analysis found that CPAP may lower cardiovascular event risk mainly in patients with high-risk obstructive sleep apnoea, especially those with stronger heart-rate surges or greater oxygen deprivation during sleep.

Critical Care news Respiratory

More Enteral Protein Did Not Overcome Anabolic Resistance in Mechanically Ventilated Critical Illness

By MedXY 05/13/2026

In a randomized trial, a 40 g intraduodenal whey bolus increased amino acid availability but did not significantly raise postprandial muscle protein synthesis versus 20 g in critically ill ventilated adults.

Critical Care news Respiratory

Predicted Body Weight May Be Too High for Many Critically Ill Women: New Evidence Challenges a Core Assumption in Lung-Protective Ventilation

By MedXY 05/12/2026

A large analysis suggests the predicted body weight equation overestimates lung size in critically ill women, increasing the risk of higher driving pressures and contributing to excess mortality under standard tidal-volume targeting.

Clinical Updates news Respiratory

Ivermectin for COVID-19: From Pandemic Controversy to Definitive Futility in the REMAP-CAP and Global Randomized Trials

By MedXY 05/12/2026

A comprehensive evidence-based synthesis of the REMAP-CAP trial and major international RCTs, demonstrating that ivermectin fails to improve clinical outcomes, survival, or organ support requirements in hospitalized and non-hospitalized COVID-19 patients.

Cardiology news Respiratory

A GOLD Science Committee Perspective on Exacerbations and Cardiovascular Risk In COPD

By MedXY 05/11/2026

COPD exacerbations significantly increase cardiovascular risk for months. This article examines the link between COPD and heart disease, emphasizing proactive screening during flare-ups and evidence-based prevention strategies to improve survival rates.

Critical Care news Respiratory

In-hospital influenza vaccination is associated with reduced 1-year mortality in critical patients with chronic pulmonary disease: a real world target trial emulation

By MedXY 05/09/2026

In critically ill chronic pulmonary disease patients, receiving influenza vaccination during hospitalization reduces 1-year mortality by 12%, lowers 90-day mortality by 12%, decreases readmission risk by 13%, and reduces emergency visits by 23%, with safety non-inferior to non-vaccinated patients.

Critical Care news Respiratory

Continuous Subphenotype Probabilities Expose High-Risk Patients Hidden Within “Hypoinflammatory” Acute Respiratory Failure

By MedXY 05/05/2026

AHRF patients classified as hypoinflammatory are not prognostically uniform. Continuous biomarker-based probabilities reveal substantial mortality heterogeneity, especially below the binary 0.5 threshold, with implications for enrichment strategies in phenotype-guided critical care trials.

Cardiology news Respiratory

Pulmonary Arterial Hypertension Therapy Preserves Gas Exchange Overall in Portopulmonary Hypertension, but New Intrapulmonary Vascular Dilatations Can Emerge

By MedXY 05/04/2026

In PoPH, PAH-specific therapy did not worsen oxygenation overall, although responses varied widely. Hemodynamic changes influenced gas exchange, and some patients developed new intrapulmonary vascular dilatations during follow-up.

Internal Medicine news Respiratory

Mild and Single Moderate COPD Exacerbations Predict Future Risks: Insights from a Community-Based Cohort Study

By MedXY 04/27/2026

Community-based COPD patients with mild or single moderate exacerbations show higher future exacerbation risks and lung structural abnormalities, despite stable lung function decline rates.

Neurology news Respiratory

Proximal Hypoglossal Nerve Stimulation Shows Promise for Moderate-to-Severe OSA in Landmark OSPREY Trial

By MedXY 04/24/2026

A recent randomized controlled trial demonstrates that proximal hypoglossal nerve stimulation significantly improves obstructive sleep apnea symptoms in patients intolerant to positive airway pressure therapy.

news Respiratory

Once-Daily Umeclidinium-Vilanterol Outperforms Other LAMA-LABA Combinations in Reducing COPD Exacerbations

By MedXY 04/13/2026

A large observational study finds that once-daily umeclidinium-vilanterol dry powder inhaler significantly reduces COPD exacerbation risk compared to glycopyrrolate-formoterol and tiotropium-olodaterol, while maintaining similar safety profiles across all three dual bronchodilator therapies.