Highlights
A randomized controlled trial in mechanically ventilated critically ill adults found that a 40 g intraduodenal whey protein bolus did not significantly increase postprandial muscle protein synthesis compared with a 20 g bolus.
The higher protein dose did increase circulating amino acid exposure, including leucine and tyrosine, showing that substrate delivery was greater but not translated into a clearly greater anabolic response in skeletal muscle.
