Neurology – Page 12

Pediatric Ischemic Stroke in Switzerland Is Still Diagnosed Too Late for Reperfusion in Most Cases

By MedXY 05/03/2026

A 24-year Swiss registry study shows modest improvement in pediatric stroke recognition, but most children are still diagnosed beyond thrombolysis and thrombectomy windows.

Neurology news Public Health

Status Epilepticus Mortality in U.S. Adults Is Rising, With the Highest Burden in Older Adults, Men, Non-Hispanic Black Populations, and the South

By MedXY 05/03/2026

A U.S. mortality analysis from 1999 to 2020 found increasing deaths from status epilepticus after 2007, with marked disparities by age, sex, race/ethnicity, and region.

Neurology news Oncology

First-Time Seizure Is Linked to a Markedly Increased Short-Term Risk of Occult Cancer

By MedXY 05/03/2026

A nationwide Danish cohort study found that adults with a first-time seizure had substantially elevated 1-year risks of neurological and nonneurological cancers, with smaller but persistent excess risk over longer follow-up.

Neurology news Pediatrics

Combined Nicotinamide Riboside and Home-Based Exercise Improved Peak VO2 Safely in Friedreich’s Ataxia

By MedXY 05/03/2026

In a phase 2 factorial trial, 12 weeks of nicotinamide riboside plus individualized exercise improved cardiopulmonary fitness in Friedreich's ataxia, with mild-to-moderate adverse events and no signal of major safety concerns.

Cardiology Neurology news

Late-Life Stroke in ARIC Was More Often Embolic, and Atrial Disease Explained Much of the Risk

By MedXY 05/01/2026

In ARIC, ischemic stroke at age 80 years or older was more often embolic than thrombotic. Atrial fibrillation and left atrial disease explained much of the age effect, and adding embolic factors improved prediction.

Neurology news Public Health

Commercially Insured Patients Wait a Median of 25 Days for New Neurology Care, with Regional and Plan-Based Differences

By MedXY 04/30/2026

Among 114,034 commercially insured patients, the median time to a new neurology visit was 25 days. Waits varied by sex, diagnosis, region, and plan type, while neurologist density showed no association with access.

$Neurofilament Light Chain Reveals Rapid Neuroaxonal Injury in New-Onset Refractory Status Epilepticus$

Critical Care Neurology news

Neurofilament Light Chain Reveals Rapid Neuroaxonal Injury in New-Onset Refractory Status Epilepticus

By MedXY 04/30/2026

In a multinational cross-sectional study, serum and CSF neurofilament light chain—unlike S100B—tracked severe acute brain injury in cryptogenic NORSE, rose rapidly over the first 3 weeks, and predicted poor short-term outcome, supporting urgent neuroprotective treatment.

Emergency Medicine Neurology news

Intracranial Hemorrhage Patterns and Outcomes in Minor Stroke: Insights from the TEMPO-2 Trial

By MedXY 04/29/2026

Secondary analysis of TEMPO-2 trial data reveals intracranial hemorrhage in minor stroke patients increases 90-day mortality risk threefold, with higher hemorrhage rates in tenecteplase-treated patients despite most bleeds being non-symptomatic.

Neurology news

Superior Efficacy of Cenobamate in Drug-Resistant Focal Epilepsy: Real-World Evidence

By MedXY 04/29/2026

This article reviews a large real-world study demonstrating cenobamate's superior effectiveness over brivaracetam, lacosamide, and perampanel in reducing seizures for adults with drug-resistant focal epilepsy.

Neurology news Pathology & Lab Medicine

Women’s Elevated P-Tau217 Levels and Faster Cognitive Decline: Implications for Preclinical Alzheimer’s Disease

By MedXY 04/28/2026

Women with high amyloid-β show higher p-tau217 levels and faster tau accumulation than men, leading to greater cognitive decline. This sex-specific tau response may redefine preclinical Alzheimer's diagnostics and therapeutics.

Neurology news Pathology & Lab Medicine

Sex-Specific Differences in P-Tau217 and Tau Aggregation: Implications for Preclinical Alzheimer’s Disease

By MedXY 04/28/2026

Women exhibit higher plasma p-tau217 levels and tau aggregation than men in amyloid-positive individuals, suggesting sex-specific pathways in Alzheimer’s disease progression.

Neurology news

Amlenetug Shows Potential in Slowing MSA Progression Despite Phase 2 Trial Missing Primary Endpoint

By MedXY 04/28/2026

The phase 2 AMULET trial evaluated amlenetug, an anti-α-synuclein monoclonal antibody, in MSA patients. While it did not meet its primary endpoint, the antibody showed a non-significant 19% slowing of disease progression with an acceptable safety profile, warranting further phase 3 investigation.

Emergency Medicine Neurology news

Stroke Disability and Mortality Post-ED Discharge for Dizziness: Rare but Clinically Significant

By MedXY 04/27/2026

A retrospective cohort study reveals that stroke-related disability or mortality after ED discharge for dizziness is rare (0.04% incidence), with most lesions occurring in the anterior fossa. Findings underscore the need for targeted risk stratification in dizziness evaluations.

Neurology news

EVT Shows Superior Outcomes in Anterior Cerebral Artery Occlusion Stroke: Insights from the ORIENTAL-MeVO Registry

By MedXY 04/25/2026

Endovascular thrombectomy (EVT) significantly improves 90-day functional outcomes in acute anterior cerebral artery occlusion stroke compared to standard medical management, without increasing hemorrhage or mortality risks, per the ORIENTAL-MeVO Registry.

Neurology news

Optimal Sleep Duration Mitigates Cognitive Decline and Dementia Risk in Focal Epilepsy: Insights from the UK Biobank Study

By MedXY 04/25/2026

A UK Biobank study reveals that optimal sleep (6-8 hours) improves executive function and reduces dementia risk in focal epilepsy patients, with effects surpassing those in stroke patients. Nonoptimal sleep exacerbates cognitive deficits up to 8 years pre-diagnosis.

Family Medicine & Nutrition Neurology news

Dementia Screening for Family Members: No Clear Benefit or Harm Found in Landmark Trial

By MedXY 04/24/2026

A randomized clinical trial found that dementia screening for family members of older adults did not improve quality of life or caregiver preparedness, nor did it increase depression or anxiety.

Neurology news Respiratory

Proximal Hypoglossal Nerve Stimulation Shows Promise for Moderate-to-Severe OSA in Landmark OSPREY Trial

By MedXY 04/24/2026

A recent randomized controlled trial demonstrates that proximal hypoglossal nerve stimulation significantly improves obstructive sleep apnea symptoms in patients intolerant to positive airway pressure therapy.

Infectious Diseases Neurology news

Combination Antiviral Therapy Improves Survival in HHV-6B Encephalitis Post-Cord Blood Transplant

By MedXY 04/24/2026

A real-world study reveals FCN/GCV combination therapy enhances 1-year survival in HHV-6B encephalitis post-CBT, particularly after neutrophil engraftment, compared to monotherapy. Findings underscore the need for tailored antiviral strategies based on hematologic recovery.

Gastroenterology Neurology news

Protein Misfolding in the Gut: A Window into Future Neurodegeneration

By MedXY 04/23/2026

GI biopsies reveal misfolded proteins years before neurological symptoms appear, offering a new biomarker for early neurodegenerative disease prediction and intervention.

Clinical Updates Neurology news

Inflammatory Biomarkers in Cerebral Venous Thrombosis: Prognostic Insights from the CLOT-VENUS Substudy and Meta-Analyses

By MedXY 04/22/2026

High admission levels of NLR, PLR, MLR, and SII are independently associated with poor functional outcomes and mortality in acute cerebral venous thrombosis, offering a low-cost tool for early risk stratification.