Posted inCritical Care Neurology news

Rising Hospital Mortality and Escalating Rates of Life-Sustaining Therapy Withdrawal in Critically Ill TBI Patients: A 15-Year Analysis

A 15-year observational study of over 45,000 TBI patients reveals a significant increase in hospital mortality and a tripling of life-sustaining therapy withdrawal, alongside rising rates of hypoxaemia, raising urgent questions about ethical frameworks and neurocritical care management.
The SEIZURE Score Faces Global Challenges: International Validation Highlights Geographic Disparities in Predicting Encephalitis Seizures
Posted inInfectious Diseases Neurology news

The SEIZURE Score Faces Global Challenges: International Validation Highlights Geographic Disparities in Predicting Encephalitis Seizures

An international evaluation of the SEIZURE score reveals limited global predictive power for acute seizures in encephalitis. While the tool performs well in Western Europe, particularly Portugal, its utility elsewhere is hampered by etiological diversity and diagnostic limitations.
High-Dose Oral Rifampin Did Not Improve Survival in Tuberculous Meningitis—HARVEST Trial Shows No Benefit and Possible Harm
Posted inInfectious Diseases Neurology news

High-Dose Oral Rifampin Did Not Improve Survival in Tuberculous Meningitis—HARVEST Trial Shows No Benefit and Possible Harm

A multinational randomized trial found that adding high‑dose oral rifampin (total 35 mg/kg for 8 weeks) to standard therapy did not reduce 6‑month mortality in adults with tuberculous meningitis and was associated with more drug‑induced liver injury and earlier deaths in some patients.
Acupuncture for Cancer-Related Insomnia: Limited, Low-Certainty Benefits Compared with Sham or No Treatment; Inferior to CBT‑I
Posted inNeurology news Oncology

Acupuncture for Cancer-Related Insomnia: Limited, Low-Certainty Benefits Compared with Sham or No Treatment; Inferior to CBT‑I

A 2025 Cochrane review (5 RCTs, 402 patients, mainly women with breast cancer) finds very low- to moderate-certainty evidence that acupuncture delivers small, uncertain sleep diary benefits versus sham or inactive controls and is probably less effective than CBT‑I for insomnia in people with cancer.
Prehospital Postintubation Hypotension Strongly Linked to 30‑Day Mortality After Severe Traumatic Brain Injury — Especially in Isolated TBI
Posted inCritical Care Emergency Medicine Neurology news

Prehospital Postintubation Hypotension Strongly Linked to 30‑Day Mortality After Severe Traumatic Brain Injury — Especially in Isolated TBI

A multicenter cohort study of 555 patients with severe TBI who underwent prehospital rapid sequence induction found postintubation hypotension (SBP <90 mmHg within 10 minutes) in 19.1%, which was associated with higher 30‑day mortality (AOR 1.70). The association was markedly stronger in isolated TBI (AOR 13.55).