Highlights
- Automated analysis of brief picture-description speech samples distinguishes PPA clinical variants with high accuracy (AUC ~0.90).
- Variant-specific speech profiles correlate with distinct neuroanatomical signatures in frontal, temporal, and parietal language regions.
- Speech profiles effectively differentiate underlying neuropathology in autopsy-confirmed cases, enhancing precision diagnosis.
- These scalable, interpretable tools offer practical advantages for settings lacking specialized speech-language pathology resources.
Background
