Allergy & Immunology – Page 5

Seborrheic Dermatitis and Epithelial Barrier Diseases: Large Cohort Studies Support a Shared Barrier‑Driven Pathogenesis

By MedXY 11/17/2025

Two large US retrospective cohort studies show seborrheic dermatitis is strongly associated with a range of epithelial barrier diseases (skin, respiratory, gastrointestinal, ocular), with evidence of bidirectional risk. Findings support the epithelial barrier theory and prompt integrated clinical awareness and mechanistic research.

Allergy & Immunology Gastroenterology news

GWAS of Idiopathic Achalasia Reveals a Strong HLA Class II–Mediated Immune Aetiology and T-Cell Involvement

By MedXY 11/07/2025

A first large GWAS in 4,602 idiopathic achalasia patients implicates class II HLA variation, PTPN22, TNFSF loci and a memory CD8+ T-cell subtype in disease pathogenesis, supporting an immune-mediated aetiology and offering routes for mechanistic work and risk stratification.

Allergy & Immunology news Respiratory

ICS–Formoterol Users Show Lower Reported Adherence but Less SABA Use: Real‑World Evidence from the MASK‑air Asthma App

By MedXY 11/02/2025

Analysis of MASK‑air app data from 2015–2022 found lower self‑reported adherence to ICS+formoterol versus other ICS+LABA combinations, but paradoxically lower short‑acting β2‑agonist (SABA) use and similar symptom control in ICS+formoterol users.

Allergy & Immunology Family Medicine & Nutrition news Oncology

How Milk Sugar Fuels Immune Cells to Fight Cancer: The Surprising Role of Galactose

By MedXY 11/01/2025

New research reveals that galactose from dietary sources like milk reprograms liver metabolism, boosting immune T cell activity to combat tumors by preventing their exhaustion.

Allergy & Immunology Dermatology news

Rilzabrutinib in Moderate-to-Severe Atopic Dermatitis: Assessing Efficacy and Safety in a Phase II Trial

By MedXY 10/28/2025

A phase II trial evaluating rilzabrutinib, a BTK inhibitor, in moderate-to-severe atopic dermatitis showed no significant improvement in primary endpoints but demonstrated rapid itch relief and a favorable safety profile.

Allergy & Immunology news Pediatrics Respiratory

Unveiling Diverse Inflammatory Pathways in Residual Pediatric Asthma Exacerbations Under Mepolizumab Therapy

By MedXY 10/27/2025

This study reveals multiple distinct molecular mechanisms, including epithelial and macrophage pathways, that contribute to residual asthma exacerbations in children treated with mepolizumab, highlighting the complexity of airway inflammation.

Allergy & Immunology Hematology-Oncology news

Long-Term Safety and Efficacy of Gene Therapy for Adenosine Deaminase Deficiency

By MedXY 10/25/2025

This study demonstrates the long-term effectiveness and safety of autologous gene therapy for treating ADA deficiency, showing sustained immune function and minimal adverse effects over a median follow-up of 7.5 years.

Allergy & Immunology Oncology

More Than Half of Patients Experience Tumor Shrinkage! Clinical Data Unveiled for a Potential “First-in-Class” Therapy

By MedXY 10/24/2025

Marengo Therapeutics reports promising Phase 2 results for invikafusp alfa, showing significant tumor shrinkage and disease control in advanced solid tumors with high mutation burden or MSI-H/dMMR.

Allergy & Immunology Otorhinolaryngology

Gender Differences in Chronic Rhinosinusitis: Insights into Diagnosis and Biomarkers

By MedXY 10/24/2025

This study explores how biological sex influences CRS diagnosis and inflammatory biomarkers, revealing sex-specific patterns that could inform personalized treatment.

Allergy & Immunology Plastic Surgery Transplantation

Unraveling Chronic Rejection in Vascularized Composite Allotransplantation: Clinical Manifestations, Mechanisms, and Future Directions

By MedXY 10/24/2025

This article explores the clinical features, underlying mechanisms, and potential therapeutic targets for chronic rejection in VCA, emphasizing the importance of tailored interventions to improve long-term graft survival.

Allergy & Immunology Family Medicine & Nutrition Pediatrics Specialties

Basophil Activation Test: A Superior Predictor for Allergic Reactions to Baked and Fresh Cow’s Milk in Children

By MedXY 10/21/2025

The Basophil Activation Test offers the highest accuracy in predicting allergic reactions to baked and fresh cow's milk during oral food challenges, reducing the need for riskier diagnostic tests in children with milk allergy.

Allergy & Immunology Nephrology

Oral Iptacopan Shows Promise in Reducing Proteinuria in C3 Glomerulopathy: Results from a Global Phase 3 Trial

By MedXY 10/10/2025

The APPEAR-C3G phase 3 trial demonstrates that oral iptacopan significantly reduces proteinuria and is well tolerated in adults with C3 glomerulopathy, an ultra-rare glomerulonephritis linked to alternative complement pathway overactivation.

Allergy & Immunology news Respiratory

Persistent Use of Green Cleaning Products Linked to Increased Asthma Risk: Implications for Clinical Practice

By MedXY 10/09/2025

Longitudinal data from the French NutriNet-Santé cohort reveal that persistent and increased use of green cleaning products is associated with a modest but significant rise in asthma symptoms, underscoring the need for cautious use and patient counseling.

Allergy & Immunology Dermatology news

Patient-Centered Insights: Understanding Treatment Preferences in Chronic Urticaria Management

By MedXY 10/08/2025

This systematic review highlights patient and caregiver priorities in chronic urticaria treatment, emphasizing rapid symptom relief, long-term effectiveness, and safety.

Allergy & Immunology Internal Medicine news

Guardians Within: The Nobel-Winning Discovery of Regulatory T Cells and Their Role in Immune Balance

By MedXY 10/06/2025

The 2025 Nobel Prize in Physiology or Medicine honors groundbreaking work on regulatory T cells, revealing how the immune system avoids self-attack while combating threats, paving the way for novel therapies in autoimmune and transplant medicine.

Allergy & Immunology Medical News news Pediatrics Public Health Specialties

In-Home Firearm Homicides Among Children and Adolescents: Understanding a Hidden Crisis

By MedXY 09/29/2025

Nearly one-quarter of firearm-related homicides of US children and adolescents occur at home, particularly affecting younger children, with domestic violence and child abuse as major factors.

Allergy & Immunology Clinical Updates news OB/GYN & Women's Health Specialties

Menopause and Multiple Sclerosis: Evaluating the Impact on Disability Progression

By MedXY 09/29/2025

A comprehensive analysis reveals that menopause does not significantly alter the risk of disability progression in women with relapse-onset multiple sclerosis, underscoring the complexity of reproductive aging's role in disease trajectory.

Allergy & Immunology Dermatology Specialties

Icotrokinra: A Promising Oral IL-23 Inhibitor Outperforms JAK Inhibitor in Psoriasis Phase 3 Trials

By MedXY 09/25/2025

In two phase 3 trials, oral IL-23 receptor inhibitor icotrokinra demonstrated superior efficacy and safety compared to the JAK inhibitor deucravacitinib in moderate-to-severe plaque psoriasis, marking a potential advancement in oral psoriasis therapies.

Allergy & Immunology Clinical Updates OB/GYN & Women's Health

Pregnancy and Disease Outcomes in Women with Moderate to Severe Multiple Sclerosis Disability

By MedXY 09/24/2025

This study evaluates how pregnancy affects relapse rates and long-term disability in women with moderate to severe multiple sclerosis (MS), showing pregnancy reduces relapse during gestation without worsening long-term disability progression.

Allergy & Immunology Neurology Pediatrics Specialties

Modulating Immune Dysregulation in Autism Spectrum Disorder: Comparative Effects of an Anti-Inflammatory Diet and Probiotic Supplementation

By MedXY 09/16/2025

A 12-week trial in children with ASD demonstrates that a structured anti-inflammatory dietary protocol (NeuroGutPlus) exerts broader immunoregulatory effects than multi-strain probiotics, highlighting diet as a promising non-pharmacological intervention for immune dysregulation in ASD.