Pediatric Differentiated Thyroid Carcinoma: Insights from the Child and Adolescent Thyroid Consortium on Invasive Disease Predictors and Treatment Outcomes

Highlight

• Pediatric differentiated thyroid carcinoma (DTC) predominantly affects females and is mostly papillary thyroid carcinoma (PTC).
• Males and children younger than 10 years have a higher likelihood of presenting with invasive disease including advanced tumor stage and metastases.
• Tumors harboring oncogenic fusions are associated with more advanced nodal and distant metastatic involvement compared with BRAFV600E mutations.
• Despite therapy deintensification implemented since 2015, disease outcomes have not deteriorated, supporting less aggressive treatment strategies in selected cases.