Introduction
Neurodegenerative movement disorders such as Parkinson’s disease (PD) and related Parkinsonian syndromes pose substantial challenges for accurate diagnosis due to the lack of definitive in vivo biomarkers, overlapping clinical symptoms, and delayed appearance of characteristic pathological features. Enhancing diagnostic precision is critical for patient management and development of targeted treatments.
This global study investigates the clinicopathological correlations, diagnostic accuracy, genetic associations with pathology, and ancestry-related pathological differences in a large, multi-ancestry cohort from multiple brain banks. It provides key insights into the complex relationships between clinical presentation, underlying brain pathology, and genetic variants, paving the way for improved diagnosis and personalized therapeutic approaches.
