High-dose rocuronium (>1.2 mg/kg) is associated with increased first-attempt intubation success in critically ill patients requiring emergency airway management.
This beneficial effect is evident primarily in intensive care unit (ICU) settings rather than emergency department (ED) settings.
Propensity-matched analysis reveals a modest but statistically significant adjusted relative risk improvement in first-attempt success with higher rocuronium dosing.
Findings emphasize the need for a prospective randomized controlled trial to confirm causality and guide dosing protocols in critical care airway management.
