A large-scale Chinese cohort study of 273,921 heart failure patients identified a U-shaped association between left ventricular end-diastolic diameter (LVEDD) and mortality.
Both abnormally small and abnormally large LV dimensions independently predict higher all-cause and cardiovascular mortality.
Sex-specific LVEDD thresholds (47 mm for men and 43 mm for women) were found optimal for mortality risk stratification.
Findings support incorporating LV dimension assessment into routine heart failure risk evaluation to guide personalized management.
