Highlights
- Curcumin selectively targets colorectal cancer stem-like cells (CSCs) in adenomas and tumors.
- Mechanistic studies reveal curcumin binds to and inhibits NANOG, a key CSC regulator.
- In vivo models confirm curcumin delays tumor onset and reduces CSC populations.
- Potential for curcumin as a preventive therapy in high-risk colorectal cancer populations.
Study Background and Disease Burden
