Curcumin supplementation significantly reduces C-reactive protein (CRP) and tumor necrosis factor-alpha (TNF-alpha) in patients with knee osteoarthritis (OA).
No significant effect observed on erythrocyte sedimentation rate (ESR), interleukin-1 beta (IL-1β), interleukin-6 (IL-6), or prostaglandin E2 (PGE-2).
Meta-analysis includes 21 randomized controlled trials (RCTs) with 1705 patients from seven countries.
Further large-scale or synovial fluid studies are needed to clarify curcumin’s anti-inflammatory mechanism in OA.
