Highlights
- Curcumin significantly reduces oxidative stress markers and apoptosis in methotrexate-induced ovarian injury.
- Antioxidant enzyme levels (SOD, CAT) increase, while MDA (a marker of lipid peroxidation) decreases with curcumin.
- Follicular reserve is preserved, with increased primordial follicle count and reduced atretic follicles.
- P53 and PARP-1 expression are modulated, suggesting a mechanistic link between curcumin’s antioxidant effects and apoptosis regulation.
Study Background and Disease Burden
