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Activity of PROTAC MDM2 Degrader in Primary Leukemia Cells and PDX Models
Posted inHematology-Oncology news Oncology

Activity of PROTAC MDM2 Degrader in Primary Leukemia Cells and PDX Models

Posted by MedXY By MedXY 05/27/2026
MD-265, a PROTAC MDM2 degrader, showed strong anti-leukemia activity in primary AML cells and mouse PDX models, outperformed a conventional MDM2 inhibitor, and spared normal stem cells relatively well.
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Curcumin Mitigates Methotrexate-Induced Ovarian Damage: Insights into Antioxidant Protection via PARP-1 and P53 Modulation
Posted inClinical Updates news

Curcumin Mitigates Methotrexate-Induced Ovarian Damage: Insights into Antioxidant Protection via PARP-1 and P53 Modulation

Posted by MedXY By MedXY 08/06/2025
Curcumin pretreatment reduces methotrexate-induced ovarian damage in rats by regulating oxidative stress and apoptosis pathways, highlighting a potential strategy for fertility preservation in chemotherapy.
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  • Comparative 1-Year Outcomes of Semaglutide, Tirzepatide, and Sleeve Gastrectomy in Obese Adults with Type 2 Diabetes: Insights from Real-World Data
  • Unveiling the Phenotype of Unclassified Pulmonary Hypertension: A Hidden Spectrum of Early Heart Failure with Preserved Ejection Fraction
  • Biomarker, Functional Status, and Quality-of-Life Trajectories Before Modes of Death in Heart Failure: Post Hoc Analysis of the FINEARTS-HF Randomized Clinical Trial
  • Decoding SLC4A3 Mutations in Short QT Syndrome: Insights from hiPSC-Derived Cardiomyocytes into Ventricular Arrhythmia and Sudden Cardiac Death
  • Decade-Long Outcomes of SAPIEN 3 TAVR vs. Surgery in Intermediate-Risk Aortic Stenosis Patients
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