Association Between Opioid Use Disorder and Hysterectomy Outcomes: A Comprehensive Clinical Review

Opioid use disorder (OUD) is associated with a statistically significant increase in composite postoperative complications in both outpatient and inpatient hysterectomy cohorts.
Inpatient hysterectomies in patients with OUD demonstrate longer hospital length of stay and substantially higher hospital charges compared to patients without OUD.
These findings underscore the need for targeted preoperative optimization and education among patients with OUD undergoing hysterectomy.
Understanding the mechanisms linking OUD and adverse surgical outcomes aids in the development of multidisciplinary management strategies to improve perioperative care.

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