The ULYSSES Trial: Ultrasound Guidance Significantly Reduces Vascular Complications in Atrial Fibrillation Ablation

Ultrasound-guided femoral venous puncture significantly reduces vascular access site complications in atrial fibrillation (AF) catheter ablation.
The ULYSSES trial, a multicenter randomized study, shows a reduction in composite vascular events from 3.3% to 0.6% with ultrasound guidance.
Secondary benefits include fewer unintended arterial punctures and a markedly lower failure rate of venous access compared to conventional palpation-guided techniques.

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