transcriptomics – Medxy AI

Blood Transcriptomic Signatures as Predictors of Poor Outcomes in Drug-Susceptible Pulmonary Tuberculosis: Insights from a Brazilian Cohort

By MedXY 09/17/2026

Host blood transcriptomic signatures effectively monitor treatment response and predict recurrence and mortality in drug-susceptible pulmonary tuberculosis, meeting WHO benchmarks and enabling personalized therapy strategies.

news OB/GYN & Women's Health

Insights into Postpartum Levator Ani Muscle Remodeling: Impact of Maternal Age and Recovery Duration on Pelvic Floor Health

By MedXY 09/07/2026

Transcriptomic analysis reveals age-related differences in levator ani muscle recovery after vaginal delivery, highlighting molecular pathways potentially contributing to pelvic organ prolapse risk in older first-time mothers.

General Surgery news Oncology

Unveiling the Molecular Evolution from Primary Gastric Cancer to Peritoneal Metastases: Implications for Targeted Surgical Oncology

By MedXY 09/05/2026

This study elucidates transcriptomic differences between primary gastric cancers and peritoneal metastases, revealing distinct tumor microenvironments and molecular pathways, highlighting potential targets for improved diagnosis and therapy in advanced gastric cancer.

Cardiology news Oncology

Decoding Hepatocellular Carcinoma in Fontan-Associated Liver Disease: Genomic and Transcriptomic Insights

By MedXY 08/12/2026

This article explores the unique genomic and transcriptomic features of hepatocellular carcinoma in Fontan-associated liver disease, revealing distinct mutation patterns and poor-prognosis molecular subtypes that inform disease mechanisms and clinical outcomes.

Gastroenterology news Pathology & Lab Medicine/Bệnh học

Decoding Liver Fibrosis in MASLD: AI-Derived Collagen Phenotypes Enhance Molecular and Clinical Insights

By MedXY 06/25/2026

This article explores a novel AI framework that identifies distinct collagen deposition patterns in MASLD, offering improved molecular specificity and prognostic value beyond traditional fibrosis assessments.

Infectious Diseases news Respiratory

Distinct Biological Pathways Drive Restrictive and Obstructive Post-Tuberculosis Lung Disease: Insights from a Kenyan Cohort

By MedXY 03/24/2026

A prospective Kenyan cohort study identifies that post-tuberculosis lung disease (PTLD) affects 50% of survivors, driven by divergent transcriptomic signatures: early pro-fibrotic inflammation in restrictive phenotypes and persistent interferon signaling in obstructive phenotypes.

Cardiology Diabetes & Endocrinology news

Six Months of Intermittent Fasting: Potent Lipid Lowering but Limited Impact on Vascular and Glycemic Markers

By MedXY 01/20/2026

A randomized controlled trial investigates the 6-month effects of intermittent fasting on overweight adults, revealing significant improvements in lipid profiles and body composition despite neutral effects on blood pressure and glucose metabolism, alongside novel transcriptomic insights into GLP-1 signaling.

Critical Care news Respiratory

Circulating Endothelial Transcriptomic Signatures Predict Worse Outcomes in COVID-19, Respiratory Failure and ARDS

By MedXY 11/07/2025

Transcriptomic deconvolution of blood identifies elevated circulating endothelial signatures (ECS%) that associate with higher 28‑day mortality and worse respiratory trajectories in pediatric respiratory failure and adults hospitalized with COVID‑19.

news Respiratory Specialties

Decoding COPD Heterogeneity: Airway Eosinophilia, Type 2 Inflammation, and Corticosteroid Responsiveness

By MedXY 09/19/2025

This study elucidates that airway eosinophilia in COPD is linked to enhanced type 2 inflammation in airway epithelium and predicts responsiveness to inhaled corticosteroids, revealing a distinct COPD endotype with potential for precision therapy.