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– Elevated circulating endothelial signatures (ECS%) derived by unsupervised bulk-transcriptome deconvolution are higher in non-survivors of respiratory failure in a pediatric cohort (CAF-PINT) and in adults hospitalized with COVID-19 (IMPACC).
– In IMPACC, each 1% increment in baseline ECS% was independently associated with 28‑day mortality (adjusted OR 1.36, 95% CI 1.03–1.79).
