Highlights
– In the HANSE prospective cohort (n=5191), PLCOm2012 (6‑year risk ≥1.58%) produced a higher positive predictive value for lung cancer detection than NELSON categorical criteria (2.59% vs 2.17%; p=0.0016).
– The number needed to screen to detect one lung cancer was lower using PLCOm2012 (38.6) than with NELSON criteria (46.1), indicating greater efficiency for risk-model selection.
