randomized controlled trial – Page 4

Harnessing AI: LLM-Based Conversational Agents Reduce Depression and Anxiety Among Young Adults in Short Video App Trial

By MedXY 09/14/2025

A 28-day RCT demonstrates that a conversational AI trained on a large language model effectively reduces mild depression and anxiety symptoms in young adults through dialog interventions integrated in short video apps.

Diabetes & Endocrinology news Specialties

Automated Insulin Delivery in Insulin-Treated Type 2 Diabetes: A Comprehensive Review of Randomized Controlled Trial Evidence and Clinical Implications

By MedXY 09/10/2025

Automated insulin delivery (AID) significantly improves glycemic control in insulin-treated type 2 diabetes, demonstrating greater HbA1c reduction and increased time in target glucose range compared to traditional insulin delivery methods.

Clinical Updates news Psychiatry Specialties Superintelligence

Evaluating a Proactive E-Health Intervention for Co-occurring At-Risk Alcohol Use and Depressive Symptoms: Adherence, Reach, and Two-Year Outcomes

By MedXY 08/25/2025

This RCT assessed a proactive e-health intervention for patients with at-risk alcohol use and depressive symptoms, showing high adherence but only small, non-significant improvements at 12 months and no lasting effects at 24 months.

Clinical Updates Specialties

Safety and Efficacy of Rotigotine in Frontotemporal Dementia: Insights from a Phase 2 Double-Blind Multicenter Trial

By MedXY 08/22/2025

This phase 2 trial found no significant cognitive or behavioral benefits of rotigotine in bvFTD patients over 24 weeks, highlighting the challenges in dopaminergic therapy for frontotemporal dementia.

Cardiology Specialties

Clinical Outcomes of Conduction System Pacing vs Right Ventricular Septal Pacing in Atrioventricular Block: Insights from the CSPACE Randomized Controlled Trial

By MedXY 08/22/2025

This review synthesizes evidence from the CSPACE RCT demonstrating superior clinical outcomes of conduction system pacing over right ventricular septal pacing in AV block patients, emphasizing reduced pacing-induced cardiomyopathy and CRT upgrade rates.

news OB/GYN & Women's Health Specialties Superintelligence

Evaluating Digital Therapeutics for Midlife Women’s Menopausal Symptoms: A Synthesis of Recent Randomized Controlled Trials

By MedXY 08/20/2025

This review synthesizes evidence on mobile digital therapeutics targeting vasomotor and behavioral health symptoms in menopausal and midlife women, highlighting efficacy, engagement, and implications for scalable symptom management.

news Psychiatry Specialties Superintelligence

Efficacy and Safety of ALM-003 Digital Therapeutic in Alcohol Dependence: A Multicenter Open-Label Randomized Controlled Trial

By MedXY 08/20/2025

This review synthesizes evidence from a multicenter RCT showing ALM-003 digital therapeutic reduces heavy drinking days significantly in alcohol-dependent individuals at high risk, with an excellent safety profile.

Cardiology news Specialties

Thoracentesis in Acute Heart Failure: Insights from the TAP-IT Randomized Controlled Trial

By MedXY 08/17/2025

The TAP-IT trial found that additional thoracentesis in acute heart failure patients with pleural effusion did not improve days alive out of hospital, mortality, or length of stay compared to standard therapy alone.

Family Medicine & Nutrition Gastroenterology news Specialties

Examining the Role of Gluten and Wheat in Irritable Bowel Syndrome: Insights from a Double-Blind, Sham-Controlled Crossover Trial

By MedXY 08/14/2025

A rigorous trial reveals that perceived symptom worsening from gluten or wheat in IBS patients may largely be driven by expectation rather than the substances themselves, underscoring the importance of distinguishing true sensitivities from placebo effects.

Critical Care news Specialties

Iloprost in Severe Septic Shock with Persistent Hypoperfusion: Insights from a Rigorous Randomized Trial

By MedXY 08/13/2025

A recent double-blind RCT shows iloprost did not reduce organ failure severity in septic shock patients with persistent hypoperfusion, highlighting challenges in improving outcomes despite theoretical benefits in microcirculation.

Cardiology Family Medicine & Nutrition news Specialties

Mediterranean Diet vs. Australian Guide to Healthy Eating: A Comparison on Body Composition and Glucose Metabolism

By MedXY 08/11/2025

This study compares the effects of the Mediterranean diet and the Australian Guide to Healthy Eating (AGHE) on body composition and glucose metabolism, revealing significant benefits of the Mediterranean diet.

Clinical Updates Diabetes & Endocrinology Family Medicine & Nutrition news Specialties

Three Weeks of Ketogenic Diet Significantly Boosts Skeletal Muscle Insulin Sensitivity in Obesity: Insights from a Randomized Crossover Trial

By MedXY 08/08/2025

A 3-week ketogenic diet improved skeletal muscle insulin sensitivity and promoted weight loss in individuals with obesity, without significant effects on liver or adipose tissue insulin sensitivity.

Clinical Updates Gastroenterology news Specialties Transplantation

Consecutive Fecal Microbiota Transplantation in MASLD: Insights from a Double-Blind Randomized Controlled Trial

By MedXY 08/07/2025

A double-blind RCT found that three consecutive fecal microbiota transplantations did not significantly improve hepatic steatosis or metabolic parameters in patients with MASLD, suggesting patient selection based on microbiota diversity may be crucial.

Clinical Updates Gastroenterology news Specialties

Low-Dose Hydrocortisone in Cirrhotic Patients With Septic Shock: A Double-Blind Randomised Placebo-Controlled Trial

By MedXY 08/06/2025

This trial evaluated low-dose hydrocortisone in cirrhotic patients with septic shock, finding no improvement in 28-day mortality or shock resolution compared to placebo.

Clinical Updates Hematology-Oncology news Specialties

Intermediate-Dose Cytarabine Matches High-Dose Efficacy with Fewer Side Effects in Postinduction AML Therapy

By MedXY 08/05/2025

A major RCT shows intermediate-dose cytarabine is noninferior to high-dose as postinduction therapy in AML, with similar survival and lower toxicity.

Clinical Updates news Orthopedics Specialties

Surgery Versus Corticosteroid Injection for Carpal Tunnel Syndrome: Insights from the DISTRICTS Randomised Controlled Trial

By MedXY 08/03/2025

The DISTRICTS trial demonstrates that initial surgical treatment for carpal tunnel syndrome leads to significantly higher recovery rates at 18 months compared to starting with corticosteroid injections, despite similar adverse event profiles.

Clinical Updates Diabetes & Endocrinology news Specialties

Continuous Glucose Monitoring in Gestational Diabetes: Insights from the DipGluMo Randomized Controlled Trial in Switzerland

By MedXY 08/02/2025

The DipGluMo trial found that real-time continuous glucose monitoring does not improve perinatal outcomes versus self-monitoring in gestational diabetes, but is preferred by patients for ease of use.

Clinical Updates news Psychiatry Specialties

Pramipexole Augmentation in Treatment-Resistant Unipolar Depression: A UK Multicentre Randomised Trial

By MedXY 08/02/2025

A UK multicentre, double-blind, placebo-controlled trial demonstrates that pramipexole augmentation at 2.5 mg reduces depressive symptoms in treatment-resistant unipolar depression at 12 weeks, with some adverse effects noted, supporting its clinical utility.