quality of life – Page 2

HNC-8D: A Head and Neck Cancer–Specific Utility Measure That Improves Discrimination of Post‑treatment Health States

By MedXY 11/21/2025

A multinational team developed and valued the HNC-8D, an 8-dimension, head and neck cancer–specific health utility instrument derived from EORTC QLQ-C30/H&N43. Valuation in 250 participants yielded mean absolute prediction errors of 0.041 (discovery) and 0.082 (validation).

news Oncology Urology

[Lutetium-177]Lu-PSMA-617 Delays Quality-of-Life Decline, Pain Progression, and Symptomatic Skeletal Events in PSMA-Positive mCRPC: In-depth PSMAfore Analysis

By MedXY 11/05/2025

PSMAfore shows that [177Lu]Lu-PSMA-617 given to taxane‑naive, PSMA-positive mCRPC patients delays worsening of health-related quality of life, pain, and first symptomatic skeletal events versus switching AR pathway inhibitors.

Neurology Public Health Rehabilitation Medicine

Long-Term Unmet Needs and Rehabilitation Gaps: Impacts on Stroke Survivors’ Quality of Life in Korea

By MedXY 10/24/2025

This study highlights how long-term unmet needs and rehabilitation deficits adversely affect the quality of life among stroke survivors in South Korea, emphasizing the need for community-based support systems.

Internal Medicine news Public Health Specialties

Enhancing Quality of Life in Older Cancer Patients: The Impact of Comprehensive Geriatric Assessment and Patient Coaching

By MedXY 10/20/2025

The G-oncoCOACH trial demonstrates that comprehensive geriatric assessment combined with geriatric team implementation and extensive patient coaching significantly improves quality of life in older patients with solid tumors undergoing systemic therapy.

Gastroenterology news Public Health

Opioid Use in Rome IV Irritable Bowel Syndrome: Prevalence and Impact on Quality of Life and Healthcare in the UK

By MedXY 10/09/2025

One in five UK patients with Rome IV IBS regularly use opioids, associated with worse quality of life, more psychological distress, and increased healthcare costs, highlighting a critical need for opioid stewardship in IBS management.

Gastroenterology news

Gut Microbiota as a Key Determinant of Quality of Life Impairment in Inflammatory Bowel Disease

By MedXY 10/09/2025

A recent cross-sectional study reveals that alterations in gut microbiota correlate more strongly with impaired health-related quality of life in IBD patients than clinical disease activity, suggesting novel microbial therapeutic targets beyond immunosuppression.

$Enhancing Quality of Life in KRASG12C-Mutated Chemorefractory Metastatic Colorectal Cancer: Insights from the CodeBreaK 300 Phase 3 Trial$

news Oncology Specialties

Enhancing Quality of Life in KRASG12C-Mutated Chemorefractory Metastatic Colorectal Cancer: Insights from the CodeBreaK 300 Phase 3 Trial

By MedXY 09/21/2025

The phase 3 CodeBreaK 300 trial shows sotorasib plus panitumumab improves health-related quality of life and clinical outcomes in KRASG12C-mutated metastatic colorectal cancer compared to standard care.

Clinical Updates news Oncology

Maintaining Quality of Life While Extending Survival: HRQoL Outcomes from KEYNOTE-966 in Advanced Biliary Tract Cancer

By MedXY 09/20/2025

The KEYNOTE-966 trial demonstrates that adding pembrolizumab to gemcitabine and cisplatin improves overall survival in advanced biliary tract cancer patients without compromising health-related quality of life.

Diabetes & Endocrinology news Specialties

Enhancing Graves’ Disease Treatment: The Benefits of Adding L-Carnitine and Selenium to Methimazole Therapy

By MedXY 09/20/2025

A recent randomized trial shows that supplementing methimazole with L-carnitine and selenium in Graves' disease shortens disease duration, lowers antibody levels faster, reduces medication dose, and improves select symptoms, highlighting a promising adjunctive therapy.

Clinical Updates news Respiratory

Dupilumab Enhances Quality of Life and Relieves Respiratory Symptoms in COPD Patients with Type 2 Inflammation: Insights from BOREAS and NOTUS Trials

By MedXY 09/19/2025

Add-on dupilumab significantly improves health-related quality of life and respiratory symptoms in COPD patients with type 2 inflammation, according to pooled results from the BOREAS and NOTUS phase 3 trials.

Clinical Updates Family Medicine & Nutrition news Specialties

Time-Restricted Eating in Overweight Adults: Effects on Sleep, Mood, and Quality of Life Remain Neutral

By MedXY 09/17/2025

A randomized clinical trial found that different timing schedules of an 8-hour time-restricted eating window combined with Mediterranean diet education did not significantly affect sleep, mood, or quality of life in adults with overweight or obesity over 12 weeks.

Oncology Specialties

Enhancing Quality of Life in ERBB2-Positive Metastatic Breast Cancer: The PRO-DUCE Trial on Electronic Symptom and Vital Sign Monitoring During Trastuzumab Deruxtecan Therapy

By MedXY 09/11/2025

The PRO-DUCE randomized trial demonstrates that electronic symptom and vital sign monitoring during trastuzumab deruxtecan therapy can preserve quality of life in ERBB2-positive metastatic breast cancer patients, with notable improvements in functional outcomes and fatigue management.

Clinical Updates Psychiatry Rheumatology

Empowering Mental Health in Inflammatory Rheumatic Diseases Through Digital Interventions: Insights from a Pilot Randomized Clinical Trial

By MedXY 09/10/2025

A pilot study demonstrates that a self-guided digital psychological intervention significantly reduces psychological distress and improves quality of life in patients with inflammatory rheumatic diseases, offering a scalable mental health support solution.

Psychiatry Rheumatology Specialties

Harnessing Digital Psychological Interventions to Improve Mental Health in Inflammatory Rheumatic Diseases: Insights from a Pilot Randomized Clinical Trial

By MedXY 09/10/2025

A pilot randomized clinical trial demonstrates that a self-guided digital psychological intervention effectively reduces psychological distress and improves quality of life among patients with inflammatory rheumatic diseases.

Clinical Updates Hematology-Oncology Specialties Transplantation

Multisite Randomized Trial of Inpatient Palliative Care in Hematopoietic Stem Cell Transplantation: Enhancing Patient and Caregiver Outcomes

By MedXY 09/09/2025

Inpatient palliative care during hematopoietic stem cell transplantation improves patients’ quality of life, reduces depression and PTSD symptoms, and offers sustained psychological benefits up to six months post-transplant.

Neurology news Psychiatry Specialties

Impact of Screening and Care for Emotional and Cognitive Problems on Post-Ischemic Stroke Outcomes: Insights from a Dutch Multicenter Cluster-Randomized Trial

By MedXY 09/04/2025

A multicenter trial assessing emotional and cognitive screening post-ischemic stroke found no improvement in societal participation at 1 year, though modest early benefits in anxiety and quality of life were noted.

Diabetes & Endocrinology news Specialties

Tirzepatide Enhances Quality of Life in Adults with Obesity or Overweight: Insights from the SURMOUNT-3 Trial

By MedXY 08/30/2025

Tirzepatide significantly improves health-related quality of life alongside weight reduction in adults with obesity or overweight, especially those experiencing physical function limitations, according to SURMOUNT-3 trial results.

Family Medicine & Nutrition Neurology news Specialties

Enhancing Quality of Life: How Exercise and Healthy Relationship Practices Improve Sexual Well-being

By MedXY 08/15/2025

Discover how specific exercises and relationship skills enhance sexual health and overall quality of life through improved communication, physical fitness, and mutual respect.

Allergy & Immunology Clinical Updates news Rheumatology Specialties

Long-term Impact of Anifrolumab on Quality of Life in Systemic Lupus Erythematosus: Insights from the TULIP-LTE Trial

By MedXY 08/03/2025

A 4-year phase 3 extension study shows that anifrolumab improves patient-reported outcomes and quality of life in systemic lupus erythematosus, with a favorable safety profile.