quality of life – Page 2

Stereotactic Radiation Preserves Quality of Life Over Hippocampal-Avoidance Whole Brain Radiation in Patients with 5 to 20 Brain Metastases

By MedXY 02/19/2026

A Phase 3 randomized trial reveals that stereotactic radiation significantly outperforms hippocampal-avoidance whole brain radiation in reducing symptom severity and interference with daily living for patients with 5 to 20 brain metastases, despite the higher tumor burden.

Gastroenterology news Oncology

Interactive Mobile Coaching Improves Long-Term Quality of Life and Symptom Management After Gastrectomy

By MedXY 01/20/2026

A randomized controlled trial demonstrates that early interactive human coaching via a mobile app improves long-term quality of life, reduces dyspnea, and eases eating restrictions in postgastrectomy patients, particularly among younger and female populations, despite not meeting its primary one-month endpoint.

Infectious Diseases Internal Medicine news

Subcutaneous Lidocaine-HP-β-CD: A Potential Disease-Modifying Breakthrough for Post-COVID Condition

By MedXY 12/29/2025

A 36-week observational study demonstrates that subcutaneous lidocaine-HP-β-CD significantly improves physical and mental quality of life and reduces symptom burden in patients with post-COVID condition, offering a scalable, home-based therapeutic option for a currently underserved patient population.

news OB/GYN & Women's Health Oncology

Simple vs Radical Hysterectomy: Balancing Survival Outcomes and Quality of Life in Early Cervical Cancer

By MedXY 12/16/2025

Evidence suggests simple hysterectomy with pelvic lymphadenectomy may offer similar survival outcomes to radical hysterectomy in early-stage cervical cancer, with fewer adverse events and better short-term quality of life.

General Surgery news OB/GYN & Women's Health Oncology

Breast Surgery in Metastatic Breast Cancer: Local Control Without Survival Benefit

By MedXY 12/16/2025

Randomised trials show breast surgery improves local disease control but not overall survival in de novo metastatic breast cancer.

news Oncology

Atezolizumab–Bevacizumab Provides the Best Balance of Survival and Quality of Life in First‑Line Advanced Hepatocellular Carcinoma

By MedXY 12/14/2025

A Bayesian network meta-analysis integrating health‑related quality of life and overall survival across first‑line trials in advanced hepatocellular carcinoma shows atezolizumab plus bevacizumab provides the most favorable combined patient‑centered outcome profile.

Critical Care news Respiratory

Five-Year Survival and Quality of Life After ECMO: Good Long-Term Outcomes but Persistent Functional Burden

By MedXY 12/11/2025

A large prospective Dutch cohort reports 36% five-year survival after ECMO with generally satisfactory health-related quality of life (median EQ-5D 0.82) but ongoing problems with pain, mobility, activities, and work capacity.

Cardiology news Radiology

Anatomic First or Invasive Angiography First? DISCHARGE Shows No QOL Advantage for CT over ICA in Stable Chest Pain

By MedXY 12/03/2025

In the DISCHARGE randomized trial prespecified secondary analysis, CT-first and ICA-first strategies produced similar long-term quality-of-life and angina outcomes in intermediate-risk stable chest pain patients over a median 3.5 years; important sex differences persisted.

news Oncology Otorhinolaryngology

HNC-8D: A Head and Neck Cancer–Specific Utility Measure That Improves Discrimination of Post‑treatment Health States

By MedXY 11/21/2025

A multinational team developed and valued the HNC-8D, an 8-dimension, head and neck cancer–specific health utility instrument derived from EORTC QLQ-C30/H&N43. Valuation in 250 participants yielded mean absolute prediction errors of 0.041 (discovery) and 0.082 (validation).

news Oncology Urology

[Lutetium-177]Lu-PSMA-617 Delays Quality-of-Life Decline, Pain Progression, and Symptomatic Skeletal Events in PSMA-Positive mCRPC: In-depth PSMAfore Analysis

By MedXY 11/05/2025

PSMAfore shows that [177Lu]Lu-PSMA-617 given to taxane‑naive, PSMA-positive mCRPC patients delays worsening of health-related quality of life, pain, and first symptomatic skeletal events versus switching AR pathway inhibitors.

Neurology Public Health Rehabilitation Medicine

Long-Term Unmet Needs and Rehabilitation Gaps: Impacts on Stroke Survivors’ Quality of Life in Korea

By MedXY 10/24/2025

This study highlights how long-term unmet needs and rehabilitation deficits adversely affect the quality of life among stroke survivors in South Korea, emphasizing the need for community-based support systems.

Internal Medicine news Public Health Specialties

Enhancing Quality of Life in Older Cancer Patients: The Impact of Comprehensive Geriatric Assessment and Patient Coaching

By MedXY 10/20/2025

The G-oncoCOACH trial demonstrates that comprehensive geriatric assessment combined with geriatric team implementation and extensive patient coaching significantly improves quality of life in older patients with solid tumors undergoing systemic therapy.

Gastroenterology news Public Health

Opioid Use in Rome IV Irritable Bowel Syndrome: Prevalence and Impact on Quality of Life and Healthcare in the UK

By MedXY 10/09/2025

One in five UK patients with Rome IV IBS regularly use opioids, associated with worse quality of life, more psychological distress, and increased healthcare costs, highlighting a critical need for opioid stewardship in IBS management.

Gastroenterology news

Gut Microbiota as a Key Determinant of Quality of Life Impairment in Inflammatory Bowel Disease

By MedXY 10/09/2025

A recent cross-sectional study reveals that alterations in gut microbiota correlate more strongly with impaired health-related quality of life in IBD patients than clinical disease activity, suggesting novel microbial therapeutic targets beyond immunosuppression.

$Enhancing Quality of Life in KRASG12C-Mutated Chemorefractory Metastatic Colorectal Cancer: Insights from the CodeBreaK 300 Phase 3 Trial$

news Oncology Specialties

Enhancing Quality of Life in KRASG12C-Mutated Chemorefractory Metastatic Colorectal Cancer: Insights from the CodeBreaK 300 Phase 3 Trial

By MedXY 09/21/2025

The phase 3 CodeBreaK 300 trial shows sotorasib plus panitumumab improves health-related quality of life and clinical outcomes in KRASG12C-mutated metastatic colorectal cancer compared to standard care.

Clinical Updates news Oncology

Maintaining Quality of Life While Extending Survival: HRQoL Outcomes from KEYNOTE-966 in Advanced Biliary Tract Cancer

By MedXY 09/20/2025

The KEYNOTE-966 trial demonstrates that adding pembrolizumab to gemcitabine and cisplatin improves overall survival in advanced biliary tract cancer patients without compromising health-related quality of life.

Diabetes & Endocrinology news Specialties

Enhancing Graves’ Disease Treatment: The Benefits of Adding L-Carnitine and Selenium to Methimazole Therapy

By MedXY 09/20/2025

A recent randomized trial shows that supplementing methimazole with L-carnitine and selenium in Graves' disease shortens disease duration, lowers antibody levels faster, reduces medication dose, and improves select symptoms, highlighting a promising adjunctive therapy.

Clinical Updates news Respiratory

Dupilumab Enhances Quality of Life and Relieves Respiratory Symptoms in COPD Patients with Type 2 Inflammation: Insights from BOREAS and NOTUS Trials

By MedXY 09/19/2025

Add-on dupilumab significantly improves health-related quality of life and respiratory symptoms in COPD patients with type 2 inflammation, according to pooled results from the BOREAS and NOTUS phase 3 trials.

Clinical Updates Family Medicine & Nutrition news Specialties

Time-Restricted Eating in Overweight Adults: Effects on Sleep, Mood, and Quality of Life Remain Neutral

By MedXY 09/17/2025

A randomized clinical trial found that different timing schedules of an 8-hour time-restricted eating window combined with Mediterranean diet education did not significantly affect sleep, mood, or quality of life in adults with overweight or obesity over 12 weeks.

Oncology Specialties

Enhancing Quality of Life in ERBB2-Positive Metastatic Breast Cancer: The PRO-DUCE Trial on Electronic Symptom and Vital Sign Monitoring During Trastuzumab Deruxtecan Therapy

By MedXY 09/11/2025

The PRO-DUCE randomized trial demonstrates that electronic symptom and vital sign monitoring during trastuzumab deruxtecan therapy can preserve quality of life in ERBB2-positive metastatic breast cancer patients, with notable improvements in functional outcomes and fatigue management.