Next-Generation Sequencing

Next-Generation Sequencing MRD Detection Predicts Outcomes in AML Patients Undergoing Allogeneic Stem Cell Transplantation

By MedXY 05/30/2026

A low-cost NGS-based MRD test detected hidden AML cells before transplant and strongly predicted worse survival after allogeneic stem cell transplantation.

Hematology-Oncology news Pediatrics

Genomic Fusion Breakpoints: A Breakthrough in Pediatric ALL MRD Monitoring

By MedXY 04/24/2026

A novel genomic fusion breakpoint (GFB)-based MRD monitoring approach demonstrates superior sensitivity and specificity in pediatric ALL, addressing limitations of current IG/TCR-based methods, particularly in ETV6::RUNX1- and MEF2D-rearranged subtypes.

Gastroenterology news

Beyond Pathology: DNA/RNA Sequencing Achieves Near-Double Sensitivity in Detecting Bile Duct Cancer

By MedXY 04/02/2026

A landmark six-year study involving over 2,000 patients at 28 institutions demonstrates that next-generation sequencing of ERCP-obtained specimens achieves 82% sensitivity for neoplastic bile duct strictures, nearly doubling traditional pathology's 44% sensitivity while maintaining 98% specificity.

Gastroenterology news Oncology

Cyst Fluid Genomics Redefine Risk: Mixed-Type IPMNs Harbor Greater Malignant Potential Than Branch-Duct Variants

By MedXY 12/23/2025

A large-scale cohort study demonstrates that mixed-type IPMNs have a three-fold higher prevalence of high-risk mutations compared to branch-duct variants, and that cyst fluid NGS provides superior diagnostic specificity over traditional clinical imaging features.