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Myofibroblasts

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Decoding Fibrosis in Lupus Nephritis: Distinct Macrophage-Fibroblast Interactions Fuel Renal Damage
Posted inNephrology news Rheumatology

Decoding Fibrosis in Lupus Nephritis: Distinct Macrophage-Fibroblast Interactions Fuel Renal Damage

Posted by By MedXY 08/17/2026
Spatially distinct macrophage subsets interact with heterogeneous myofibroblast populations in lupus nephritis, driving maladaptive fibrosis and chronic kidney injury. Identifying these fibroinflammatory circuits offers promising targets for therapy to prevent renal decline.
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From Compensation to Collapse: How Cardiac Myofibroblasts and UCP2 Genetic Variants Dictate Right Ventricular Fate in PAH
Posted inCardiology news Respiratory

From Compensation to Collapse: How Cardiac Myofibroblasts and UCP2 Genetic Variants Dictate Right Ventricular Fate in PAH

Posted by By MedXY 03/09/2026
This study identifies the transition of cardiac fibroblasts to myofibroblasts as a critical driver of right ventricular failure in PAH, highlighting the role of UCP2 deficiency and the rs659366 SNP as key clinical indicators of decompensation.
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