intermediate AMD – Medxy AI

Early Retinal Sensitivity Decline in Intermediate AMD: Insights from Lesion-Centered Functional Trajectories in the PINNACLE Study

By MedXY 08/18/2026

This article summarizes key findings from the PINNACLE study on localized retinal sensitivity loss in intermediate age-related macular degeneration (iAMD), highlighting spatial vulnerability patterns and lesion-specific functional decline trajectories.

news Ophthalmology

Predicting Progression in Intermediate AMD: The Crucial Role of Ellipsoid Zone Integrity and Quantitative OCT Biomarkers

By MedXY 08/11/2026

Quantitative OCT biomarkers, especially ellipsoid zone integrity and hyperreflective foci, strongly predict 2-year progression from intermediate to advanced atrophic AMD, offering potential for early risk stratification and targeted intervention.

Clinical Updates news Ophthalmology

Tomographic Predictors of Foveal Versus Extrafoveal Atrophy Onset in Intermediate Age-Related Macular Degeneration: Clinical Implications and Biomarker Insights

By MedXY 07/13/2026

Distinct baseline foveal tomographic lesions predict foveal-first versus extrafoveal-first cRORA onset in iAMD. Hyperreflective foci and lesion type inform risk stratification and timing of atrophic progression relevant for emerging dry AMD therapies.