International Validation of Sepsis Temperature-Trajectory Subphenotypes Reveals Immune and Coagulation Profiles with Implications for Immunoglobulin Therapy
Posted inCritical Care Infectious Diseases news

International Validation of Sepsis Temperature-Trajectory Subphenotypes Reveals Immune and Coagulation Profiles with Implications for Immunoglobulin Therapy

This study validates temperature-trajectory sepsis subphenotypes in a large Chinese ICU cohort, linking immune and coagulation dysfunction with mortality and highlighting differential responses to immunoglobulin therapy, particularly benefit in hypothermic patients.
HPV-Associated Anal Dysplasia in Solid Organ Transplant Recipients: Exploring Transplant-Specific Mucosal Immune Dysregulation
Posted inInfectious Diseases news Oncology Transplantation

HPV-Associated Anal Dysplasia in Solid Organ Transplant Recipients: Exploring Transplant-Specific Mucosal Immune Dysregulation

Solid organ transplant recipients exhibit heightened risk for HPV-associated anal dysplasia and cancer due to unique immunosuppressive alterations. A transplant-tailored model of mucosal immune dysfunction elucidates mechanisms driving persistent HPV infection and dysplasia progression, informing future screening and therapeutic strategies.