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immune checkpoint inhibitors

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Early ctDNA Variation as a Prognostic Biomarker in dMMR/MSI-H Metastatic Colorectal Cancer Treated with Immune Checkpoint Inhibitors: Insights from the SAMCO-PRODIGE 54 Trial
Posted inOncology Pathology & Lab Medicine Specialties

Early ctDNA Variation as a Prognostic Biomarker in dMMR/MSI-H Metastatic Colorectal Cancer Treated with Immune Checkpoint Inhibitors: Insights from the SAMCO-PRODIGE 54 Trial

Posted by By MedXY 08/23/2025
A secondary analysis of the SAMCO-PRODIGE 54 trial reveals that early changes in circulating tumor DNA predict long-term outcomes in dMMR/MSI-H metastatic colorectal cancer patients treated with immune checkpoint inhibitors.
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Dual Immune Checkpoint Blockade with Neoadjuvant Chemoradiotherapy in Rectal Cancer: Insights from the CHINOREC Trial
Posted inOncology Radiology Specialties

Dual Immune Checkpoint Blockade with Neoadjuvant Chemoradiotherapy in Rectal Cancer: Insights from the CHINOREC Trial

Posted by By MedXY 08/23/2025
The CHINOREC phase 2 trial demonstrates that adding ipilimumab and nivolumab to standard neoadjuvant chemoradiotherapy in rectal cancer is safe and feasible, showing promising clinical activity but no significant improvement in complete response rates.
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