Fractional Flow Reserve

FFR-Guided PCI Demonstrates Decade-Long Superiority Over Medical Therapy in Stable CAD: The FAME 2 Trial

By MedXY 02/04/2026

The 11-year FAME 2 trial results confirm that FFR-guided PCI significantly improves outcomes for stable CAD patients with functionally significant lesions, primarily by reducing urgent revascularizations, reinforcing the importance of physiological assessment in revascularization decisions.

Cardiology news

Validating the 0.80 FFR Threshold: Long-Term Outcomes from the NOTION-3 Trial in TAVR Patients

By MedXY 01/17/2026

The NOTION-3 trial demonstrates that FFR-guided revascularization significantly reduces cardiovascular risks in TAVR patients with coronary artery disease, validating the 0.80 threshold for clinical decision-making.

Cardiology news

Coronary Collaterals Attenuate Chest Pain in Stable Angina: Evidence From an Invasive Placebo‑Controlled N‑of‑1 Study

By MedXY 12/02/2025

An invasive, placebo‑controlled n‑of‑1 study shows that greater coronary collateral flow is associated with higher ischemic burden but lower pain intensity during controlled coronary occlusion, helping explain the weak correlation between stenosis severity and angina symptoms.

Cardiology Clinical Updates Radiology Specialties

FFR-Guided Complete Revascularization Enhances Outcomes in NSTEMI with Multivessel Disease: Insights from the SLIM Trial

By MedXY 09/01/2025

The SLIM trial demonstrates that fractional flow reserve–guided complete revascularization during the index procedure significantly reduces major adverse events at one year in patients with NSTEMI and multivessel disease, primarily by lowering repeat revascularizations.

Cardiology Radiology Specialties

Long-Term Comparative Outcomes of FFR vs IVUS-Guided PCI in Intermediate Coronary Stenosis: Insights from the FLAVOUR Trial Extended Follow-Up

By MedXY 08/22/2025

The FLAVOUR trial's extended 6.3-year follow-up shows equivalent long-term outcomes for FFR- and IVUS-guided PCI strategies in intermediate coronary stenosis, with FFR associated with fewer total PCIs but slight increases in late revascularization.