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diffusion MRI

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Early Detection of Cerebral Small Vessel Disease: Diffusion MRI Reveals a Decade-Long Preclinical Phase Before White Matter Hyperintensities
Posted inNeurology news Radiology

Early Detection of Cerebral Small Vessel Disease: Diffusion MRI Reveals a Decade-Long Preclinical Phase Before White Matter Hyperintensities

Posted by By MedXY 09/08/2026
Diffusion MRI detects microstructural brain changes up to 16 years before white matter hyperintensities appear, offering a valuable early window for cerebral small vessel disease intervention and improved risk stratification.
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Free Water Collapse in Limbic White Matter Predicts Memory Decline in Aging and Alzheimer Disease
Posted inNeurology news

Free Water Collapse in Limbic White Matter Predicts Memory Decline in Aging and Alzheimer Disease

Posted by By MedXY 12/10/2025
A large multisite analysis (n=4,467) finds white matter free water (FW), especially in limbic tracts (cingulum, fornix), strongly associates with cross-sectional cognition and longitudinal decline; FW interacts with amyloid, APOE ε4, and gray matter atrophy to predict worse outcomes.
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