COVID-19 – Medxy AI

Long-Term Healthcare Utilization After COVID-19: Varied Patterns Based on Initial Infection Severity

By MedXY 09/01/2026

This study analyzes healthcare usage up to 12 months after COVID-19 infection, revealing prolonged increased utilization—especially among hospitalized patients—highlighting ongoing care needs for survivors.

Clinical Updates news Public Health

Telemedicine Critical Care Billing Among Hospitalized Medicare Fee-For-Service Beneficiaries: Trends, Determinants, and Implications from 2018 to 2024

By MedXY 08/10/2026

This review synthesizes evidence on the adoption and billing practices of telemedicine critical care for Medicare beneficiaries from 2018 to 2024, highlighting pandemic-driven shifts, provider and hospital characteristics influencing utilization, and the need for further evaluation of clinical and economic outcomes.

Clinical Updates news Public Health

Estimated Effectiveness of 2024-2025 COVID-19 Vaccines in Adults: A Comprehensive Review of Recent Evidence

By MedXY 08/07/2026

This review synthesizes recent evidence on the effectiveness of 2024-2025 COVID-19 vaccines in adults, highlighting moderate protection against symptomatic illness, hospitalization, and critical outcomes, with emphasis on waning immunity and variant-specific dynamics.

Critical Care news Respiratory

Interleukin-6 as a Central Mediator of Therapeutic Success in Acute Lung Injury and COVID-19

By MedXY 08/06/2026

This article examines interleukin-6 (IL-6) as a key mediator of therapeutic efficacy in acute lung injury and COVID-19, highlighting its role in modulating inflammation and survival outcomes across multiple clinical interventions.

Cardiology Infectious Diseases news

Navigating Uncertainty: Rapid Evidence Generation and Translation of Anticoagulation Strategies in Noncritically Ill COVID-19 Patients

By MedXY 07/30/2026

This article reviews the accelerated evidence generation for anticoagulation in noncritically ill COVID-19 patients, highlighting how coordinated trials and data sharing influenced clinical guidelines and patient outcomes during the pandemic.

Infectious Diseases news OB/GYN & Women’s Health

Persistent Elevated Risk of Severe COVID-19 Outcomes in Pregnant and Postpartum Individuals Beyond the Pandemic Emergency

By MedXY 07/10/2026

Pregnant and postpartum individuals continue to face higher risks of severe COVID-19 outcomes, including hospitalization and pneumonia, even after the pandemic emergency has ended, emphasizing the need for ongoing vigilance and tailored clinical management.

Internal Medicine news Public Health

VA Health Professions Trainees Were Disrupted by COVID-19 but Became Meaningful Contributors to Clinical Care, Telehealth, and System Response

By MedXY 05/30/2026

A qualitative VA study found that COVID-19 reduced trainee learning opportunities and heightened safety concerns, yet trainees contributed substantially to care delivery, telehealth expansion, patient support, and local pandemic planning.

Critical Care news Respiratory

Prone Positioning for Severe Hypoxemia Rose Sharply During COVID-19 but Was Not Sustained Across North American ICUs

By MedXY 05/27/2026

In 37 North American hospitals, proning of eligible mechanically ventilated patients increased markedly during COVID-19, then fell post-pandemic, with substantial interhospital variation throughout.

Clinical Updates news Respiratory

Ivermectin for COVID-19: From Pandemic Controversy to Definitive Futility in the REMAP-CAP and Global Randomized Trials

By MedXY 05/12/2026

A comprehensive evidence-based synthesis of the REMAP-CAP trial and major international RCTs, demonstrating that ivermectin fails to improve clinical outcomes, survival, or organ support requirements in hospitalized and non-hospitalized COVID-19 patients.

Infectious Diseases Internal Medicine news

Ensitrelvir Demonstrates Potent Antiviral Efficacy Comparable to Nirmatrelvir in Early COVID-19: Insights from the PLATCOV Trial

By MedXY 02/25/2026

The PLATCOV trial identifies ensitrelvir as a highly effective oral antiviral, achieving rapid SARS-CoV-2 clearance comparable to ritonavir-boosted nirmatrelvir. This phase 2 adaptive trial suggests ensitrelvir is a viable alternative for outpatient management, potentially overcoming limitations associated with ritonavir-boosted regimens.

Infectious Diseases news Public Health

Beyond Symptom Resolution: Physiological Recovery Lags Behind Subjective Wellness in COVID-19 and Influenza

By MedXY 02/16/2026

A 2-year prospective cohort study reveals that physiological recovery, measured via smartwatches, significantly lags behind self-reported symptom resolution, particularly in moderate-to-severe COVID-19 cases, suggesting a need for revised post-infection activity guidelines and precision monitoring.

Infectious Diseases news Public Health

RSV Frequently Precedes Influenza Peaks: Mapping the Temporal Sequence of the Post-Pandemic Triple-Threat in the United States

By MedXY 02/08/2026

A retrospective study of 148 state-level seasons reveals that RSV typically peaks three weeks before influenza, while COVID-19 lacks consistent seasonality, providing a critical framework for optimizing hospital resource allocation and vaccination timing.

Infectious Diseases news Public Health

2024-2025 COVID-19 Vaccines Provide 79% Protection Against Critical Illness Despite Viral Evolution

By MedXY 02/06/2026

A multicenter study reveals that 2024-2025 COVID-19 vaccines offer 40% protection against hospitalization and 79% against critical illness or death, maintaining efficacy against emerging JN.1 descendants like KP.3.1.1 and XEC.

news Psychiatry Public Health

Beyond the Initial Surge: Critical Lessons for Clinical Mental Health Care from the COVID-19 Pandemic

By MedXY 01/29/2026

This article examines the Lancet Psychiatry Standing Commission's findings on mental health care delivery during COVID-19, highlighting the disproportionate impact on vulnerable groups, the rise of Long COVID, and the urgent need for evidence-based interventions in future global health crises.

Clinical Updates Emergency Medicine news Respiratory

Awake Prone Positioning in COVID-19 Respiratory Failure: A Synthesis of Clinical Trial Evidence and the PROVID Study

By MedXY 01/02/2026

This review synthesizes the findings of the PROVID randomized clinical trial and broader literature, demonstrating that awake prone positioning (APP) significantly reduces the probability of intubation and death in patients with COVID-19 hypoxemic respiratory failure.

Clinical Updates Infectious Diseases news OB/GYN & Women's Health

The Role of COVID-19 Vaccination in Improving Maternal and Perinatal Outcomes: A Comprehensive Review

By MedXY 12/24/2025

Vaccination against SARS-CoV-2 during pregnancy significantly lowers risks of severe maternal COVID-19, hospitalization, critical care admission, and preterm birth across variant periods, underscoring its safety and efficacy for maternal and neonatal health.

Infectious Diseases Internal Medicine news

Targeted Monoclonal Antibody Therapy: Sotrovimab Shows Mortality Benefit in Hospitalized COVID-19 Patients with High Antigen Loads

By MedXY 12/23/2025

The RECOVERY trial demonstrates that sotrovimab significantly reduces 28-day mortality in hospitalized COVID-19 patients with high baseline serum antigen levels, highlighting the potential for biomarker-guided monoclonal antibody therapy despite the challenges of evolving viral variants.

Infectious Diseases news

Ensitrelvir Matches Ritonavir‑Boosted Nirmatrelvir for Rapid SARS‑CoV‑2 Clearance — PLATCOV Phase 2 Results Support an Alternative Oral Mpro Inhibitor

By MedXY 11/23/2025

Phase 2 PLATCOV results show oral ensitrelvir accelerates SARS‑CoV‑2 clearance versus no drug and has antiviral effects close to ritonavir‑boosted nirmatrelvir, supporting further phase 3 evaluation.

Critical Care news Respiratory

Circulating Endothelial Transcriptomic Signatures Predict Worse Outcomes in COVID-19, Respiratory Failure and ARDS

By MedXY 11/07/2025

Transcriptomic deconvolution of blood identifies elevated circulating endothelial signatures (ECS%) that associate with higher 28‑day mortality and worse respiratory trajectories in pediatric respiratory failure and adults hospitalized with COVID‑19.

Critical Care Infectious Diseases news Pediatrics

Surge in Invasive Streptococcus pyogenes Infections Among Children Post-COVID-19: Insights from a Spanish Nationwide Study

By MedXY 10/27/2025

A Spanish multicenter study reveals a sharp rise in pediatric invasive group A streptococcal infections and severity after 2022, highlighting emm1 strain predominance and risk factors for critical illness and mortality.