autophagy – Medxy AI

Oxidized Phospholipid PGPC Impedes Angiogenesis by Disrupting Endothelial Autophagy via NPC1-Mediated Syntaxin 17 Modification

By MedXY 10/10/2026

The oxidized phospholipid PGPC inhibits angiogenesis in ischemic heart disease by impairing endothelial autophagic flux through NPC1-induced acetylation and ubiquitination of syntaxin 17, unveiling new potential therapeutic targets for coronary artery disease.

Gastroenterology news

Gut: Targeting Kupffer Cell Autophagy May Be A Novel Approach to Modulate CD8+ T Cell Activation in Primary Biliary Cholangitis

By MedXY 08/24/2026

This article explores how autophagy in Kupffer cells influences CD8+ T cell activation and contributes to primary biliary cholangitis, highlighting potential therapeutic interventions targeting macrophage autophagy to alleviate liver inflammation and bile duct damage.

Cardiology Clinical Updates news Specialties

Repurposing Antihypertensive Drug Trazosin to Delay Vascular Aging: A Breakthrough in Atherosclerosis Management

By MedXY 09/18/2025

New research identifies transcription factor ATF3 as a key regulator of vascular smooth muscle cell aging and reveals low-dose trazosin, a commonly used antihypertensive, as a potential therapy to delay vascular aging and atherosclerosis progression via autophagy enhancement.

Family Medicine & Nutrition Gastroenterology news Specialties

Linarin as a Multifaceted Therapeutic Agent for NAFLD: Modulation of PI3K/Akt/mTOR, Autophagy, and Gut Microbiota

By MedXY 09/07/2025

Linarin shows promise in mitigating NAFLD by enhancing autophagy via PI3K/Akt/mTOR inhibition, reducing inflammation, and restoring gut microbiota balance, alongside activating the PDE4D/cAMP/PKA/CREB pathway to improve hepatic lipid metabolism and oxidative stress.

Cardiology Family Medicine & Nutrition news Specialties

Divergent Impacts of Low- and High-Protein Fasting-Mimicking Diets on Cardiometabolic Health and Autophagy

By MedXY 08/30/2025

A 7-day randomized study shows that both low- and high-protein fasting-mimicking diets improve cardiometabolic health and autophagy, with high-protein variants uniquely enhancing visceral fat reduction, lipid profiles, heart rate variability, and gut microbiome diversity.