Ophthalmology – Page 4

Pigmentary Glaucoma Shows Higher Procedure Use and Worse Early Failure After LTP and MIGS Than Primary Open-Angle Glaucoma

By MedXY 05/13/2026

A large IRIS Registry study found that pigmentary glaucoma undergoes more glaucoma procedures than POAG and has higher early failure after LTP and MIGS, with notable racial differences in disease severity.

Diabetes & Endocrinology news Ophthalmology

Tocilizumab Shows Promising Benefits in Glucocorticoid-Resistant Thyroid Eye Disease

By MedXY 05/13/2026

In two prospective cohorts of active, glucocorticoid-resistant thyroid eye disease, tocilizumab improved eye inflammation, proptosis, diplopia, and quality of life with acceptable safety, supporting IL-6 blockade as a promising second-line treatment.

news Ophthalmology

Genotype-phenotype correlations in RPGRIP1-associated retinal dystrophy in a nationwide Japanese cohort

By MedXY 05/11/2026

Study identifies distinct clinical patterns in Japanese patients with RPGRIP1 mutations: Leber congenital amaurosis shows severe early vision loss while achromatopsia features progressive degeneration. Exon 18 deletion emerges as a founder variant.

news Ophthalmology Pediatrics

Web-Based Amblyopia Decision Support Tool

By MedXY 05/11/2026

The Amblyopia Navigator offers evidence-based guidance for eye care professionals to improve early detection and treatment of childhood amblyopia, addressing specialist shortages through accessible digital tools.

Clinical Updates news Ophthalmology

Clobetasol Propionate Ophthalmic Suspension 0.05%: A New Therapeutic Milestone in Post-Cataract Surgery Inflammation and Pain Management

By MedXY 05/11/2026

This review synthesizes clinical evidence for CPN 0.05% (BYQLOVI®), highlighting its rapid efficacy, superior pain resolution, and favorable safety profile compared to traditional ocular steroids following cataract surgery.

news Ophthalmology Public Health

Most Patients Reach 20/40 After Cataract Surgery, but the Current MIPS Success Metric May Misclassify Quality and Exclude Nearly Half of Cases

By MedXY 05/09/2026

A large multicenter study found that MIPS measure 191 captures high cataract surgery success rates but excludes many patients and may require case-mix adjustment to support fair surgeon comparisons.

news Ophthalmology Public Health

Large Multi-Center EMR Cohort Suggests NSAID Exposure Is Associated With Lower Future Risk of Age-Related Macular Degeneration

By MedXY 05/08/2026

In a large TriNetX retrospective cohort, prescribed NSAID use was associated with a lower subsequent risk of AMD, including both non-exudative and exudative disease, though residual confounding limits causal inference.

news Ophthalmology

The Impact of Medication Storage Location on Glaucoma Eyedrop Adherence: A Home-Based Assessment Using Electronic Monitoring

By MedXY 05/04/2026

Study reveals storing glaucoma eyedrops in kitchens or bathrooms improves adherence by 60-70% compared to bedrooms, with evening doses most frequently missed. Environmental factors like lighting showed minimal impact.

news Oncology Ophthalmology

MBD4 Germline Variants Mark a Strong Predisposition to Uveal Melanoma, Supporting Broad Genetic Screening

By MedXY 05/04/2026

A large French case series found pathogenic or likely pathogenic germline MBD4 variants in 23 of 896 patients with uveal melanoma, corresponding to a 31-fold relative risk versus the general population.

news Ophthalmology Pediatrics

No Clear Winner in Severe Congenital Ptosis Repair: AAO Review Finds Overlapping Efficacy but Distinct Surgical Risks in Children

By MedXY 05/04/2026

An American Academy of Ophthalmology review found that frontalis flap, frontalis suspension, and maximal levator resection show overlapping success and exposure rates in severe congenital ptosis, with surgical choice often guided more by complication profiles than by proven superiority.

Diabetes & Endocrinology news Ophthalmology

Teprotumumab for Thyroid Eye Disease Carries a Measurable Long-Term Dysglycemia Risk

By MedXY 05/03/2026

A large multinational cohort study found that teprotumumab use in thyroid eye disease was associated with higher risks of prediabetes, diabetes, and antidiabetes medication initiation over 5 years.

Clinical Updates Diabetes & Endocrinology news Ophthalmology

Glucagon-Like Peptide-1 Receptor Agonists and Vascular Protection: Mitigating Systemic and Ocular Risks in High-Risk Type 2 Diabetes

By MedXY 04/27/2026

A large-scale cohort study demonstrates that GLP-1 RAs significantly reduce macrovascular and microvascular complications, including proliferative retinopathy and retinal vein occlusion, in patients with pre-existing diabetic retinopathy.

Diabetes & Endocrinology news Ophthalmology

Brolucizumab Outperforms Laser Therapy in Proliferative Diabetic Retinopathy: Insights from the CONDOR Trial

By MedXY 04/27/2026

The CONDOR trial demonstrates brolucizumab's superiority over panretinal photocoagulation in preserving vision and reducing disease progression in proliferative diabetic retinopathy, offering a potential shift in treatment paradigms.

news Ophthalmology Pediatrics

DSDO Lenses Show Superior Axial Length Control in Pediatric Myopia Management: A Real-World Multicenter Study

By MedXY 04/27/2026

DSDO lenses demonstrated significant efficacy in slowing axial elongation in myopic and non-myopic children, with pronounced effects in younger age groups and low myopia subgroups during the first 6 months of intervention.

news Ophthalmology Pediatrics

Whole Genome Sequencing Outperforms Gene Panels in Diagnosing Congenital Cataracts

By MedXY 04/23/2026

Whole genome sequencing (WGS) increases diagnostic yield by 10% compared to gene panels in congenital cataracts, aiding in prognosis, reproductive counseling, and management.

news Ophthalmology

Personalized Glaucoma Coaching Boosts Medication Adherence by 20%: SEE Program Trial Results

By MedXY 04/23/2026

A 6-month personalized coaching program (SEE) significantly improved glaucoma medication adherence by 19.7% compared to standard education, reducing vision loss risk in a randomized trial of 235 patients.

news Ophthalmology

High Glaucoma Risk in Pseudoexfoliation Syndrome: Age and Ocular Hypertension Drive Incidence

By MedXY 04/23/2026

New study reveals 26.5-37.5% of eyes with pseudoexfoliation syndrome develop glaucoma within 4 years, with ocular hypertension doubling risk. Standalone lens extraction reduced IOP by 3 mmHg.

news Ophthalmology

Association of Deep Optic Nerve Head Structural Remodeling with Choroidal Microvasculature Dropout in Glaucoma with and without Myopia

By MedXY 04/21/2026

Study reveals significant links between optic nerve head structural changes and choroidal microvascular dropout in glaucomatous eyes, particularly in myopia. Deep structural parameters like neural canal geometry strongly correlate with microvascular damage severity.

news Ophthalmology Pediatrics

Open Globe Repair Carries the Highest Endophthalmitis Risk, and Pediatric Cataract Surgery Outpaces Adult Surgery in IRIS Registry Data

By MedXY 04/21/2026

An IRIS Registry analysis of 17.5 million procedures found endophthalmitis was rare overall but highest after open globe repair, with pediatric cataract surgery carrying more risk than adult surgery.

news Ophthalmology

Challenging the Assumption: Fellow-Eye Correlations in Geographic Atrophy Progression Prove Modest at Best

By MedXY 04/11/2026

A post hoc analysis of AREDS2 reveals that geographic atrophy enlargement rates between fellow eyes show only modest correlations, challenging the common assumption that bilateral GA progresses similarly. The findings have important implications for clinical trial design and the use of fellow eyes as internal controls.