The ISOLD score demonstrated high diagnostic accuracy for vitreoretinal lymphoma (VRL) using intraocular cytokine levels, especially in aqueous humor (AH) samples.
The score outperformed the conventional IL-10/IL-6 ratio by providing a continuous probabilistic assessment.
False-negative results primarily occurred in immunosuppressed patients receiving corticosteroids or chemotherapy, emphasizing clinical context in interpretation.
Vitreous sample data, though limited, indicate excellent ISOLD performance but require further validation through larger studies.
