A scalable, community-based antihypertensive intervention led by nonphysician providers significantly improved cardiovascular health metrics over 36 months.
Blood pressure improvement was the primary driver of cardiovascular risk reduction, accounting for over two-thirds of the intervention’s benefit.
Concurrent behavioral and metabolic improvements contributed modestly but meaningfully to risk reduction when combined with blood pressure control.
Multidomain response heterogeneity provides a valuable framework for tailoring multifaceted cardiovascular intervention strategies.
