Four distinct cardiovascular subphenotypes were identified in ICU patients with sepsis using unsupervised clustering of echocardiographic and hemodynamic data.
These subphenotypes correlate with varying mortality rates and reflect different mechanisms of circulatory failure.
Simple three-variable models accurately classify patients into these subphenotypes in both derivation and validation cohorts.
Subphenotype-specific responses to vasoactive agents and fluid therapies suggest a potential for personalized hemodynamic treatment in septic shock.
