Cardiology – Page 17

Food Delivery After Heart Failure Hospitalization Was Feasible but Did Not Reduce 90-Day HF Readmissions

By MedXY 06/10/2026

A randomized trial found that medically tailored meals and fresh produce were highly feasible after HF hospitalization, but neither strategy improved the primary 90-day heart failure utilization outcome versus usual care.

Allergy & Immunology Cardiology news

Macrophage circHIPK2 Silencing Reduces Post-Infarction Inflammation and Fibrosis and Improves Cardiac Recovery

By MedXY 06/10/2026

A 2026 European Heart Journal study identifies macrophage circHIPK2 as a regulator of post-MI inflammation and fibrosis, with macrophage-targeted silencing improving cardiac remodeling in mice and showing translational promise in human myocardial tissue models.

Cardiology Diabetes & Endocrinology news

Tirzepatide Produced Broad 72-Week Improvements in Cardiovascular Risk Biomarkers Across Inflammatory, Metabolic, Endothelial, and Thrombotic Pathways in Obesity

By MedXY 06/10/2026

In a SURMOUNT-1 post hoc analysis, tirzepatide improved multiple cardiovascular risk biomarkers over 72 weeks in obesity, with the largest and most consistent effects seen for inflammation, insulin resistance, adiposity-related markers, endothelial dysfunction, and fibrinolytic balance.

Cardiology news

Higher Resting Heart Rate Still Signals Risk After Myocardial Infarction, and Stopping β-Blockers Raises Heart Rate Without Identifying a Safe Subgroup

By MedXY 06/10/2026

A secondary analysis of ABYSS shows that in stable post-MI patients with preserved ejection fraction, higher heart rate remains prognostic and β-blocker interruption increases heart rate by about 10–13 bpm while worsening outcomes across heart-rate strata.

Cardiology news

Role of Atrial Pacing Support in Cardiac Resynchronization Therapy: A Noninferiority Randomized Trial

By MedXY 06/10/2026

A randomized trial found that a two-lead CRT-D system without atrial pacing was noninferior to standard three-lead CRT-D in selected heart failure patients, with fewer atrial lead-related complications.

Cardiology news Public Health

A Genome-First Study of Familial Hypercholesterolemia in African and European Ancestry Individuals

By MedXY 06/10/2026

A genome-first study found similar rates of pathogenic FH variants in African and European ancestry groups, but uncertain variants were more common and potentially more harmful in African ancestry individuals, highlighting the need for more inclusive genetic classification.

Cardiology Clinical Updates news

Olfactory Receptor Signaling as a Novel Antiplatelet Strategy: OR2L13 Activation, HSP27 Phosphorylation, and Cytoskeletal Control of Arterial Thrombosis

By MedXY 06/10/2026

A 2026 Circulation study identifies OR2L13 agonism as a first-in-class platelet inhibitory strategy that suppresses aggregation and arterial thrombosis through HSP27-dependent actin remodeling without an apparent hemostatic penalty in preclinical models.

Cardiology news

WNT5a Signaling Disruption Drives Cardiac Pathogenesis in LMNA-Related Emery-Dreifuss Muscular Dystrophy

By MedXY 06/10/2026

Aberrant WNT5a-mediated actin filament dynamics underlie cardiac dysfunction and arrhythmias in LMNA-related Emery-Dreifuss Muscular Dystrophy, revealing novel therapeutic targets via RhoA activation and actin stabilization.

Cardiology news

Determining the Physiological Threshold for Angina (ORBITA-FIRE): A Double-Blind, Randomized, Placebo-Controlled Study

By MedXY 06/10/2026

ORBITA-FIRE shows that angina occurs at much lower, individualized FFR and RFR thresholds than standard ischemia cutoffs, and these thresholds rise with exercise intensity.

Allergy & Immunology Cardiology news

Cardiac Sarcoidosis May Be Driven by a Heart-Resident Autoimmune B-Cell Axis Linked to Periplakin

By MedXY 06/10/2026

Single-cell and spatial transcriptomics suggest that cardiac sarcoidosis evolves through region-specific inflammatory programs and intracardiac B-cell autoimmunity, with periplakin emerging as a candidate autoantigen.

Cardiology news Public Health

Cold Weather Triggers Acute Heart Failure Decompensation, but Hemodynamic Phenotypes Show Opposite Temperature Risks

By MedXY 06/10/2026

A large Tokyo case-crossover study found that short-term exposure to low ambient temperature increases acute heart failure admissions, especially in older adults, while patients with hypotensive presentations may be more vulnerable to heat.

Cardiology Diabetes & Endocrinology news

Precision Prescribing of SGLT2 Inhibitors in Type 2 Diabetes for Primary Prevention of Heart Failure

By MedXY 06/10/2026

A validation study developed SABRE, a model that estimates how much SGLT2 inhibitors can reduce heart failure risk in people with type 2 diabetes, helping clinicians target preventive treatment more precisely.

Cardiology Diabetes & Endocrinology news

Precision Prescribing of SGLT2 Inhibitors in People With Type 2 Diabetes for Primary Prevention of Heart Failure: Model Development and Validation Study

By MedXY 06/10/2026

The SABRE model estimates which people with type 2 diabetes may benefit most from SGLT2 inhibitors to prevent heart failure before it develops.

Cardiology news Public Health

Sex-Based Patterns and Trends in Transcatheter Aortic Valve Implantation

By MedXY 06/10/2026

A nationwide Medicare study found that women made up a declining share of TAVI patients, had more periprocedural complications, but slightly better long-term survival than men. The findings support sex-specific planning and follow-up in aortic valve care.

Cardiology news

Great Debate: Is the New Risk Factor-Weighted Clinical Likelihood Model Useful for Estimating Pre-Test Probability of Obstructive Coronary Artery Disease?

By MedXY 06/10/2026

The RF-CL model is a new ESC-recommended tool for estimating the pre-test probability of obstructive CAD in suspected chronic coronary syndromes. It improves risk stratification and may reduce unnecessary testing, though symptom interpretation and practical limits remain debated.

Cardiology Hematology-Oncology news

The Fibrinogen αC Region Promotes Arterial Thrombosis in Hypofibrinogenemia

By MedXY 06/10/2026

Low fibrinogen alone did not prevent arterial thrombosis in humans or mice, but loss of the fibrinogen αC region reduced clot formation. The study suggests fibrinogen structure, not just level, influences arterial thrombotic risk.

Cardiology Neurology news

Acute Cardiac CT Added to Stroke Imaging Detects Cardiac Thrombi in About 1 in 16 Patients and Outperforms Transthoracic Echocardiography

By MedXY 06/10/2026

In a 3919-patient individual-level meta-analysis, acute cardiac CT detected cardiac thrombi in 6.2% of ischemic stroke cases, exceeded transthoracic echocardiography yield, added modest imaging burden, and identified patients with worse 90-day outcomes.

Cardiology Internal Medicine news

More ANOCA Endotypes, More Angina: Comprehensive Coronary Function Testing Reveals a Graded Symptom Burden

By MedXY 06/09/2026

In patients with ANOCA, overlapping coronary endotypes were common, and each additional abnormality identified on comprehensive coronary function testing was associated with significantly worse angina burden.

Cardiology Nephrology news

Finerenone May Lower Sudden Death Risk Across the Cardio-Kidney-Metabolic Continuum

By MedXY 06/09/2026

A prespecified pooled analysis of 18,991 participants found finerenone was associated with a significant reduction in sudden death across chronic kidney disease, type 2 diabetes, and heart failure populations.

Cardiology Internal Medicine news

SRPK3-Driven TPM1 Splicing Emerges as a Myofilament Mechanism of Diastolic Dysfunction in HFpEF

By MedXY 06/09/2026

A Circulation study identifies SRPK3-mediated alternative splicing of TPM1 exon 9a as a driver of myofibrillar disarray, reduced myocardial compliance, and diastolic dysfunction in HFpEF, highlighting a potential disease-modifying therapeutic target.