Highlight
– Extended 28-day venous thromboembolism (VTE) chemoprophylaxis with once-daily subcutaneous enoxaparin is standard after pancreatectomy for malignancy.
– This large single-institution retrospective analysis found no significant reduction in symptomatic postoperative VTE rates with extended prophylaxis.
– Higher body mass index (BMI) independently predicts increased risk of VTE after hospital discharge despite prophylaxis.
– Findings highlight the inadequacy of current prophylaxis dosing and underscore the potential need for weight-based VTE prevention strategies.
