Prenatal Maternal Depression as a Critical Developmental Risk Factor: Large-Scale IPD Meta-Analysis of 76,514 Children

Highlights

Prenatal maternal depression is associated with a significant increase in offspring behavioral and developmental symptoms, including higher internalizing, externalizing, ADHD, and ASD scores (6.61-10.90 percentile points).

Associations between prenatal depression and child outcomes were found to be similar across both male and female offspring, suggesting a non-sex-specific developmental vulnerability.

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