新西兰早期药物流产随访方式优化：随机对照试验证实自我评估优于血清bhCG检测
Posted inClinical Updates OB/GYN & Women's Health

Enhancing Follow-Up After Early Medical Abortion in New Zealand: Evidence from a Randomised Controlled Trial on Self-Assessment versus Serum bhCG Testing

A New Zealand RCT demonstrates that self-assessment with low sensitivity urine pregnancy tests after early medical abortion improves complete follow-up and successful abortion rates compared to serum bhCG testing, supporting safer, equitable reproductive healthcare.
MASH治疗新进展：miricorilant 1b期研究结果积极，间歇给药方案更具潜力
Posted inClinical Updates Diabetes & Endocrinology Gastroenterology

Miricorilant in Metabolic Dysfunction-Associated Steatohepatitis: Promising Phase 1b Results Highlight Intermittent Dosing Strategy

This phase 1b study of miricorilant, a selective glucocorticoid receptor modulator, shows significant reductions in liver fat and improvements in liver health markers in patients with presumed metabolic dysfunction-associated steatohepatitis, particularly with intermittent dosing.
亨廷顿病中的多巴胺拮抗剂：来自安慰剂对照试验 PROOF-HD 的证据
Posted inClinical Updates Neurology

Antidopaminergic Medications and Clinical Outcomes in Huntington Disease: Insights From the PROOF-HD Placebo-Controlled Trial

This review synthesizes evidence from the PROOF-HD placebo arm and related studies, demonstrating that antidopaminergic medication use in Huntington disease correlates with accelerated decline in functional, motor, and cognitive outcomes, emphasizing the need for careful consideration in clinical trials and management.
数字疗法可显著减轻慢性髌股关节疼痛
Posted inClinical Updates Orthopedics

Integrated Digital Therapeutic Combining Exercise and Cognitive-Behavioural Therapy Significantly Reduces Chronic Patellofemoral Pain: A Multicentre RCT

An 8-week smartphone-based digital therapeutic offering personalized exercise and cognitive-behavioural therapy significantly improved pain, knee function, quality of life, and psychological outcomes in patients with chronic patellofemoral pain compared with education and exercise instruction alone.
难治性转移性结直肠癌简化14天曲氟尿苷-替吡嘧啶联合贝伐珠单抗方案的非劣效性：PRABITAS试验解读
Posted inClinical Updates Oncology

Non-Inferiority of a Simplified 14-Day Trifluridine-Tipiracil plus Bevacizumab Regimen for Refractory Metastatic Colorectal Cancer: Insights from the PRABITAS Trial

The PRABITAS trial demonstrated that a 14-day trifluridine-tipiracil plus bevacizumab regimen is non-inferior to the conventional 28-day schedule in refractory metastatic colorectal cancer, with significantly reduced hematological and gastrointestinal toxicities.
儿童盘状红斑狼疮进展为系统性红斑狼疮的风险：来自多中心队列研究的启示
Posted inClinical Updates Dermatology Rheumatology

Risk of Progression from Pediatric Discoid Lupus Erythematosus to Systemic Lupus Erythematosus: Insights from a Multicenter Cohort Study

This study quantifies the risk and identifies predictors for systemic lupus erythematosus development in children presenting with skin-limited discoid lupus erythematosus, highlighting the importance of early monitoring especially in patients positive for antinuclear antibodies.