Highlights
– The PERMET randomized, double-blind trial (n=202) tested whether metformin improves 6-minute walk distance in people with lower extremity PAD without diabetes; it found no benefit at 6 months.
– Primary outcome: adjusted between-group difference in 6-minute walk was 1.1 m (95% CI, -16.3 to 18.6 m; P = .90), far below the minimum clinically important difference (8–20 m).
