Impact of Induction Course Number on Outcomes of Allogeneic Stem Cell Transplant with Post-Transplant Cyclophosphamide in AML

Highlight

  • Analysis of 677 adult AML patients undergoing allogeneic stem cell transplantation (alloHSCT) with post-transplant cyclophosphamide (PTCy) in first complete remission.
  • Comparison between patients achieving CR1 after one induction chemotherapy course versus those requiring two courses.
  • Similar overall survival, leukemia-free survival, and GVHD-free/relapse-free survival despite higher relapse incidence in the two-induction group.
  • Findings support alloHSCT with PTCy as effective regardless of induction course number needed for remission.

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