Highlight
– Addition of combined L-carnitine and selenium supplementation to methimazole (MMI) therapy accelerates TSH-receptor antibody (TRAb) normalization in Graves’ disease (GD).
– The intervention group also exhibits reduced methimazole dosing requirements and a significantly higher rate of spontaneous remission.
– Although overall symptom burden was similar, supplementation independently improved severity of tremor, irritability, mood lability, heat intolerance, and exertional dyspnea.
