Explainable Artificial Intelligence for Predicting Refractory Ulcerative Colitis: Insights from a Japanese Nationwide Registry

Introduction

Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by inflammation of the colon lining. Its clinical course varies widely, and remission often depends on corticosteroid (CS) therapy. However, some patients develop refractory UC, where inflammation persists despite treatment, necessitating tailored therapeutic strategies. Understanding the prognostic factors that predict treatment response is crucial for optimizing patient outcomes.

Objective

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