Divergent Metabolic Impacts of Ketogenic Versus Free-Sugar-Restricted Diets: Insights from a 12-Week Randomized Controlled Trial

Highlights

  • Low free-sugar or carbohydrate intake reduces body fat but not energy expenditure
  • Restricting sugar lowers LDL-C with minimal impact on metabolism or gut microbiome
  • Four weeks of a ketogenic diet increases atherogenic lipoprotein profile
  • The ketogenic diet alters gut microbial beta diversity and skeletal muscle phenotype

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