Highlight
- Spatial proteomics profiling of nearly 200 NSCLC tumors reveals distinct oncogene-driven remodeling of the immune tumor microenvironment (TME).
- EGFR- and KRAS-mutant tumors exhibit reduced cytotoxic T cell infiltration and distinct immunosuppressive niches, including enrichment of M2-like tumor-associated macrophages in EGFR mutants.
- Spatial analyses identify immune cell neighborhoods and proximity patterns that significantly correlate with patient prognosis, underscoring the clinical relevance of immune architecture.
- Findings suggest that mutation-specific immune microenvironments could inform personalized immunotherapeutic interventions in NSCLC.
Study Background
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For clinical reference; use professional judgment.
